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Titolo:
Lipoolygosaccharide indirectly enhances inflammatory lesions in lungs as aprimary infection site by non-encapsulated and type B Haemophilus influenzae through production of cytokines
Autore:
Miyazaki, S; Nunoya, T; Matsumoto, T; Furuya, N; Tateda, K; Yamaguchi, K;
Indirizzi:
Toho Univ, Sch Med, Dept Microbiol, Ota Ku, Tokyo 143, Japan Toho Univ Tokyo Japan 143 Med, Dept Microbiol, Ota Ku, Tokyo 143, Japan Nippon Inst Biol Sci, Tokyo, Japan Nippon Inst Biol Sci Tokyo JapanNippon Inst Biol Sci, Tokyo, Japan
Titolo Testata:
CYTOKINE
fascicolo: 3, volume: 15, anno: 2001,
pagine: 171 - 174
SICI:
1043-4666(20010807)15:3<171:LIEILI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHIAL EPITHELIAL-CELLS; NECROSIS-FACTOR-ALPHA; LIPOPOLYSACCHARIDE;
Keywords:
cytokine production; LOS; inflammatory lesion; H. Influenzae;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Miyazaki, S Toho Univ, Sch Med, Dept Microbiol, Ota Ku, 5-21-16 Omori Nishi, Tokyo 143, Japan Toho Univ 5-21-16 Omori Nishi Tokyo Japan 143 okyo 143, Japan
Citazione:
S. Miyazaki et al., "Lipoolygosaccharide indirectly enhances inflammatory lesions in lungs as aprimary infection site by non-encapsulated and type B Haemophilus influenzae through production of cytokines", CYTOKINE, 15(3), 2001, pp. 171-174

Abstract

We investigated the role of cytokines in differences in histopathologic changes in the lung between bronchopneumonia caused by non-encapsulated Haemophilus influenzae strain 770235f(0)b(0) and systemic disease caused by typeb H. influenzae strain 770235f(0)b(+). Tumour necrosis factor-alpha (TNF-alpha), interleukin-(IL)-6 and IL-1 beta levels in bronchoalveolar lavage fluid (BALF) samples of mice infected with strain 770235f(0)b(0) were higher than in those infected with strain 770235f(0)b(0) until 24 h post-infection. Serum IL-6 rapidly increased in strain 770235f(0)b(0) infection after 72 h post-infection. Serum TNF-alpha level in strain 770235f(0)b(0) infection appeared earlier than in strain 770235f(0)b(0) infection. IL-1 beta production in strain 770235f(0)b(+) infection was later than in strain 770235f(0)b(0) infection. Moreover, a biphasic concentration pattern of TNF-alpha and IL-6 was noted in BALF of mice with strain 770235f(0)b(0) infection. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 07:53:00