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Titolo:
Tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-induced apoptosis is dependent on activation of cysteine and serine proteases
Autore:
Park, IC; Park, MJ; Woo, SH; Lee, KH; Lee, SH; Rhee, CH; Hong, SI;
Indirizzi:
Korea Canc Ctr Hosp, Cell Biol Lab, Seoul 139240, South Korea Korea Canc Ctr Hosp Seoul South Korea 139240 , Seoul 139240, South Korea
Titolo Testata:
CYTOKINE
fascicolo: 3, volume: 15, anno: 2001,
pagine: 166 - 170
SICI:
1043-4666(20010807)15:3<166:TNFAIL>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOCHROME-C RELEASE; DEATH; RECEPTORS; FAMILY; TRAIL; IDENTIFICATION; MITOCHONDRIA; PROTEIN; MEMBER;
Keywords:
apoptosis; caspases; gastric cancer; serine protease; TRAIL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Hong, SI Korea Canc Ctr Hosp, Cell Biol Lab, 215-4 Gongneung Dong, Seoul 139240, South Korea Korea Canc Ctr Hosp 215-4 Gongneung Dong Seoul South Korea 139240
Citazione:
I.C. Park et al., "Tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-induced apoptosis is dependent on activation of cysteine and serine proteases", CYTOKINE, 15(3), 2001, pp. 166-170

Abstract

We examined the role of caspases and serine protease(s) in cell death induced by tumour necrosis factor-related apoptosis-inducing ligand (TRAIL). After incubation of adenocarcinoma cells with TRAIL, caspase-3, -8 were activated and the cleavage of Bid induced the release of cytochrome c, from the mitochondria to the cytosol. Tetrapeptide inhibitors of caspase-1, -2, -3, and -8 suppressed DNA fragmentation and attenuated the release of cytochrome c, whereas inhibitors of caspase-5 did not. Interestingly, the general serine protease(s) inhibitor 4-(2-aminoethyl)benzylsulfonyl fluoride (AEBSF) resulted in the arrest of apoptosis. However, the AEBSF did not prevent therelease of mitochondrial cytochrome c during TRAIL-induced apoptosis. Fromthese results, we postulate that serine protease(s) may be involved in post-mitochondrial apoptotic events, that lead to the activation of the initiator, caspase-9. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:15:22