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Titolo:
Retroviral transduction model of mixed lineage leukemia fused to CREB binding protein
Autore:
Liedman, D; Zeleznik-Le, N;
Indirizzi:
Loyola Univ, Med Ctr, Maywood, IL 60153 USA Loyola Univ Maywood IL USA 60153 ola Univ, Med Ctr, Maywood, IL 60153 USA
Titolo Testata:
CURRENT OPINION IN HEMATOLOGY
fascicolo: 4, volume: 8, anno: 2001,
pagine: 218 - 223
SICI:
1065-6251(200107)8:4<218:RTMOML>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYELOID-LEUKEMIA; MLL GENE; HISTONE ACETYLTRANSFERASE; DNA-BINDING; MYELODYSPLASTIC SYNDROME; SET DOMAINS; HRX-ENL; CBP; TRANSLOCATION; CHROMOSOME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Zeleznik-Le, N Loyola Univ, Med Ctr, 2160 S 1st Ave,Bldg 112,Room 337, Maywood, IL 60153 USA Loyola Univ 2160 S 1st Ave,Bldg 112,Room 337 Maywood IL USA 60153
Citazione:
D. Liedman e N. Zeleznik-Le, "Retroviral transduction model of mixed lineage leukemia fused to CREB binding protein", CURR OPIN H, 8(4), 2001, pp. 218-223

Abstract

The in-frame fusion of mixed lineage leukemia to CREB binding protein has been cloned from several patients with t-acute myeloid leukemia and a t(11;16)(q23;p13). A murine retroviral transduction model of mixed lineage leukemia fused to CREB binding protein successfully recapitulates the disease. Interestingly, the mice also develop a preleukemic phase reminiscent of whatis often seen in patients with t(11;16). From this work, it was determinedthat minimally, the amino terminus of mixed lineage leukemia fused to the bromodomain and histone acetyltransferase domain of CREB binding protein are necessary for developing acute myeloid leukemia. This model provides a useful tool for understanding the biologic basis of mixed lineage leukemia leukemogenesis and for developing and testing potential therapeutic agents. Curr Opin Hematol 2001, 8:218-223 (C) 2001 Lippincott Williams & Wilkins, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:28:57