Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Central imidazoline (I-1) receptors modulate aqueous hydrodynamics
Autore:
Ogidigben, MJ; Potter, DE;
Indirizzi:
Morehouse Sch Med, Dept Pharmacol Toxicol, Atlanta, GA 30310 USA MorehouseSch Med Atlanta GA USA 30310 col Toxicol, Atlanta, GA 30310 USA Merck & Co Inc, Merck Res Labs, Dept Pharmacol, W Point, PA USA Merck & CoInc W Point PA USA Res Labs, Dept Pharmacol, W Point, PA USA
Titolo Testata:
CURRENT EYE RESEARCH
fascicolo: 5, volume: 22, anno: 2001,
pagine: 358 - 366
SICI:
0271-3683(200105)22:5<358:CI(RMA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROSTRAL VENTROLATERAL MEDULLA; ESSENTIAL-HYPERTENSION; MOXONIDINE; AGONIST; CLONIDINE; RABBITS; PRESSURE; RATS;
Keywords:
intracerebroventricular injection; imidazoline (I-1) receptors; intraocular pressure; moxonidine; efaroxan; sympathectomy; aqueous flow;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Potter, DE Morehouse Sch Med, Dept Pharmacol Toxicol, Atlanta, GA 30310 USA Morehouse Sch Med Atlanta GA USA 30310 , Atlanta, GA 30310 USA
Citazione:
M.J. Ogidigben e D.E. Potter, "Central imidazoline (I-1) receptors modulate aqueous hydrodynamics", CURR EYE R, 22(5), 2001, pp. 358-366

Abstract

The purpose of this work is to determine the relative contributions of central imidazoline (I-1) receptors to the ocular hydrodynamic action of moxonidine. Moxonidine (MOX), an alpha (2) and I-1 receptor agonist, and efaroxan (EFA), a relatively selective I-1 antagonist, were utilized to study alterations in intraocular pressure (IOP) and aqueous flow in New Zealand whiterabbits subjected to intracerebroventricular (i.c.v.) cannulation and sympathectomy. Intracerebroventricular administration of MOX (0.033, 0.33 and 3.33 mug) to normal rabbits produced dose-dependent, bilateral IOP decreasesof 3, 6, and 8 mmHg, respectively. The ocular hypotensive response to MOX was immediate (10 min. post drug), lasted for one hour, and was inhibited by prior administration of efaroxan (3.33 mug icv). In unilaterally sympathectomized (SX) rabbits, the ocular hypotensive response induced by i.c.v MOXin the denervated eye was attenuated approximately 50%, but the duration of ocular hypotension in the surgically altered eye was longer than that of the normal eye. MOX (0.33 mug icv), caused a statistically significant decrease (2.24 to 1.59ml/min.) in aqueous flow in normal eyes. In SX eyes, there was no change in aqueous flow by MOX, suggesting that IOP effect in icv MOX observed in the SX eye might be mediated by changes in outflow resistance. Sedation was observed in all the rabbits treated with MOX (icv) and was dose-dependent. These in vivo data support the suggestion that centrally located I-1 receptors modulate the early contralateral response to topically administered MOX and are involved in lowering of IOP and aqueous flow in rabbit. In addition, expression of the fall ocular hypotensive effect of centrally applied MOX depends on intact sympathetic innervation. Ocular hypotension induced by MOX in the SX eye may involve an effect on uveoscleral outflow.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 03:31:01