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Titolo:
Evolution of Ftz protein function in insects
Autore:
Alonso, CR; Maxton-Kuechenmeister, J; Akam, M;
Indirizzi:
Univ Cambridge, Dept Zool, Lab Dev & Evolut, Cambridge CB2 3EJ, England Univ Cambridge Cambridge England CB2 3EJ lut, Cambridge CB2 3EJ, England
Titolo Testata:
CURRENT BIOLOGY
fascicolo: 18, volume: 11, anno: 2001,
pagine: 1473 - 1478
SICI:
0960-9822(20010918)11:18<1473:EOFPFI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE FUSHI-TARAZU; BEETLE TRIBOLIUM-CASTANEUM; DROSOPHILA EMBRYOS; NUCLEAR RECEPTOR; SEGMENTATION; EXPRESSION; COMPLEX; NEUROGENESIS; MELANOGASTER; POLYPEPTIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Akam, M Univ Cambridge, Dept Zool, Lab Dev & Evolut, Downing St, CambridgeCB2 3EJ, England Univ Cambridge Downing St Cambridge England CB2 3EJ 3EJ, England
Citazione:
C.R. Alonso et al., "Evolution of Ftz protein function in insects", CURR BIOL, 11(18), 2001, pp. 1473-1478

Abstract

The Drosophila, gene fushi tarazu (ftz) encodes a homeodomain-containing transcriptional regulator (Ftz) required at several stages during development. Drosophila melanogaster ftz (Dm-ftz) is first expressed in seven stripesdefining alternate parasegments of the embryo-a "pair-rule" segmentation function [1, 2]. It is then expressed in specific neural precursor cells in the central nervous system and finally in the developing hindgut [3]. An Orthopteran ortholog of ftz (Sg-ftz, formally Dax) has been isolated from thegrasshopper Schistocerca gregaria [4]. The pattern of Sg-ftz expression inSchistocerca, embryos suggests that some developmental roles of the ftz gene are likely to be conserved between these two species (e.g., CNS functions) while others may have diverged (e.g., segmentation functions). To test whether the function of the Ftz protein itself differs between these two species, here we compare the functions of Sg-Ftz and Dm-Ftz proteins by expressing both in Drosophila embryos. Sg-ftz mimics only poorly several segmentation roles of Dm-ftz (engrailed activation, wingless repression, and embryonic cuticle transformation). However, the two proteins are similarly activein the rescue of a CNS-specific ftz mutant. These findings argue that thisftz CNS function is mediated by conserved parts of the protein, while efficient pair-rule function requires sequences present specifically in the Drosophila protein.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/06/20 alle ore 01:46:48