Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effect of ketamine on the neuromagnetic mismatch field in healthy humans
Autore:
Kreitschmann-Andermahr, I; Rosburg, T; Demme, U; Gaser, E; Nowak, H; Sauer, H;
Indirizzi:
Univ Jena, Dept Psychiat, D-07740 Jena, Germany Univ Jena Jena Germany D-07740 ena, Dept Psychiat, D-07740 Jena, Germany Rhein Westfal TH Aachen, Dept Neurosurg, D-52074 Aachen, Germany Rhein Westfal TH Aachen Aachen Germany D-52074 , D-52074 Aachen, Germany Univ Jena, Dept Forens Med, D-07740 Jena, Germany Univ Jena Jena GermanyD-07740 a, Dept Forens Med, D-07740 Jena, Germany Univ Jena, Dept Anesthesiol, D-07740 Jena, Germany Univ Jena Jena Germany D-07740 , Dept Anesthesiol, D-07740 Jena, Germany JENASENSORIC, Jena, Germany JENASENSORIC Jena GermanyJENASENSORIC, Jena, Germany
Titolo Testata:
COGNITIVE BRAIN RESEARCH
fascicolo: 1, volume: 12, anno: 2001,
pagine: 109 - 116
SICI:
0926-6410(200108)12:1<109:EOKOTN>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUDITORY SENSORY MEMORY; NEGATIVITY GENERATION; EVOKED-POTENTIALS; SCHIZOPHRENIA; PSYCHOSIS; RECEPTOR; VOLUNTEERS; DYSFUNCTION; MODEL;
Keywords:
schizophrenia; information processing; mismatch negativity; auditory evoked potential; ketamine; NMDA receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Kreitschmann-Andermahr, I Univ Jena, Dept Psychiat, D-07740 Jena, Germany Univ Jena Jena Germany D-07740 0 Jena, Germany
Citazione:
I. Kreitschmann-Andermahr et al., "Effect of ketamine on the neuromagnetic mismatch field in healthy humans", COGN BRAIN, 12(1), 2001, pp. 109-116

Abstract

Mismatch negativity (MMN) is a component of the auditory evoked event-related potentials (ER-P) that assesses automatic sound change detection and isdisturbed in schizophrenic patients. Animal experimental evidence has linked the generation of MMN to the N-methyl-D-aspartate (NMDA) receptor. We investigated the neuromagnetic mismatch field (MMF) in healthy volunteers before and after intravenous application of a subanesthetic dose of the NMDA receptor antagonist ketamine (0.3 mg/kg). Ketamine had a significant influence on latency and dipole moment of the MMF, whereas the N100m latency of the standard tone was not prolonged and its dipole moment remained stable. Our results suggest that ketamine interferes with aspects of preattentive information processing and is in line with the view that disturbed NMDA receptor function may mediate the deficient auditory mismatch response in patients with schizophrenia. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:11:40