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Titolo:
An overview of the role and inter-relationship of epidermal growth factor receptor, cyclin D and retinoblastoma protein on the carcinogenesis of squamous cell carcinoma of the larynx
Autore:
Rafferty, MA; Fenton, JE; Jones, AS;
Indirizzi:
Univ Liverpool, Dept Otolaryngol Head & Neck Surg, Liverpool L69 3GA, Merseyside, England Univ Liverpool Liverpool Merseyside England L69 3GA , Merseyside, England
Titolo Testata:
CLINICAL OTOLARYNGOLOGY
fascicolo: 4, volume: 26, anno: 2001,
pagine: 317 - 320
SICI:
0307-7772(200108)26:4<317:AOOTRA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGNOSTIC-SIGNIFICANCE; BREAST-CANCER; GENE AMPLIFICATION; EPITHELIAL-CELLS; EGF RECEPTOR; NECK-CANCER; EXPRESSION; HEAD; OVEREXPRESSION; PROGRESSION;
Keywords:
laryngeal squamous cell carcinoina; EGFR; cyclin D; retinoblastoma protein; molecular biology immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Jones, AS Univ Liverpool, Dept Otolaryngol Head & Neck Surg, Duncan Bldg,Daulby St, Liverpool L69 3GA, Merseyside, England Univ Liverpool Duncan Bldg,Daulby St Liverpool Merseyside England L69 3GA
Citazione:
M.A. Rafferty et al., "An overview of the role and inter-relationship of epidermal growth factor receptor, cyclin D and retinoblastoma protein on the carcinogenesis of squamous cell carcinoma of the larynx", CLIN OTOLAR, 26(4), 2001, pp. 317-320

Abstract

Recent developments in both molecular and cellular biology have improved the understanding of the tumorigenesis of laryngeal squamous cell carcinoma. Loco-regional recurrence of this condition still poses a significant oncological management dilemma for a subset of these tumours. Therefore, the possibility that specific tumour characteristics (demonstrable by immunohistochemical and molecular biological study) may aid the clinician in choosing the optimal treatment for a specific tumour holds great promise. This article concentrates on the role and inter-relationship of epidermal growth factor receptor status on the function of cyclin D, and how this is related to the presence of retinoblastoma protein. A review of recent studies evaluating these markers, the potential clinical utility of these findings and the possible directions for further study are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:08:59