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Titolo:
Simultaneous infection with multiple strains of Mycobacterium tuberculosis
Autore:
Braden, CR; Morlock, GP; Woodley, CL; Johnson, KR; Colombel, AC; Cave, MD; Yang, ZH; Valway, SE; Onorato, IM; Crawford, JT;
Indirizzi:
Ctr Dis Control & Prevent, Div TB Eliminat, Natl Ctr Human Immunodeficiency Virus Sexually Tr, Natl Ctr Infect Dis, Atlanta, GA USA Ctr Dis Control &Prevent Atlanta GA USA Ctr Infect Dis, Atlanta, GA USA Ctr Dis Control & Prevent, Div Acquired Immune Deficiency Syndrome STD & TB, Natl Ctr Infect Dis, Atlanta, GA USA Ctr Dis Control & Prevent Atlanta GA USA Ctr Infect Dis, Atlanta, GA USA Ctr Dis Control & Prevent, Epidem Intelligence Serv, Div Appl Publ Hlth Training, Atlanta, GA USA Ctr Dis Control & Prevent Atlanta GA USA Hlth Training, Atlanta, GA USA Washington State Dept Hlth, Olympia, WA USA Washington State Dept Hlth Olympia WA USA ate Dept Hlth, Olympia, WA USA Washington State Dept Hlth, Seattle, WA USA Washington State Dept Hlth Seattle WA USA ate Dept Hlth, Seattle, WA USA Cent Arkansas Vet Hlth Care Syst, Little Rock, AR USA Cent Arkansas Vet Hlth Care Syst Little Rock AR USA Little Rock, AR USA
Titolo Testata:
CLINICAL INFECTIOUS DISEASES
fascicolo: 6, volume: 33, anno: 2001,
pagine: E42 - E47
SICI:
1058-4838(20010915)33:6<E42:SIWMSO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXOGENOUS REINFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Braden, CR Ctr Dis Control & Prevent, Div Bacterial & Mycot Dis, Mailstop A-38,1600 Clifton Rd, Atlanta, GA 30333 USA Ctr Dis Control & Prevent Mailstop A-38,1600 Clifton Rd Atlanta GA USA 30333
Citazione:
C.R. Braden et al., "Simultaneous infection with multiple strains of Mycobacterium tuberculosis", CLIN INF D, 33(6), 2001, pp. E42-E47

Abstract

Drug-susceptible and drug-resistant isolates of Mycobacterium tuberculosiswere recovered from 2 patients, 1 with isoniazid-resistant tuberculosis (patient 1) and another with multidrug-resistant tuberculosis (patient 2). Aninvestigation included patient interviews, record reviews, and genotyping of isolates. Both patients worked in a medical-waste processing plant. Transmission from waste was responsible for at least the multidrug-resistant infection. We found no evidence that specimens were switched or that cross-contamination of cultures occurred. For patient 1, susceptible and isoniazid-resistant isolates, collected 15 days apart, had 21 and 19 restriction fragments containing IS6110, 18 of which were common to both. For patient 2, a single isolate contained both drug-susceptible and multidrug-resistant colonies, demonstrating 10 and 11 different restriction fragments, respectively. These observations indicate that simultaneous infections with multiple strains of M. tuberculosis occur in immunocompetent hosts and may be responsible for conflicting drug-susceptibility results, though the circumstances of infections in these cases may have been unusual.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:33:12