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Titolo:
Reduction of p12(DOC-1) expression is a negative prognostic indicator in patients with surgically resected oral squamous cell carcinoma
Autore:
Shintani, S; Mihara, M; Terakado, N; Nakahara, Y; Matsumura, T; Kohno, Y; Ohyama, H; McBride, J; Kent, R; Todd, R; Tsuji, T; Wong, DTW;
Indirizzi:
Harvard Univ, Sch Dent Med, Dept Oral Med & Diagnost Sci, Div Oral Pathol,Lab Mol Pathol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 hol,Lab Mol Pathol, Boston, MA 02115 USA Forsyth Inst, Boston, MA 02115 USA Forsyth Inst Boston MA USA 02115Forsyth Inst, Boston, MA 02115 USA Okayama Univ, Sch Dent, Dept Oral & Maxillofacial Surg 2, Okayama 700, Japan Okayama Univ Okayama Japan 700 Maxillofacial Surg 2, Okayama 700, Japan
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 9, volume: 7, anno: 2001,
pagine: 2776 - 2782
SICI:
1078-0432(200109)7:9<2776:ROPEIA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR GENE; CYCLIN D1 EXPRESSION; NECK-CANCER; MOLECULAR-BIOLOGY; NUCLEAR ANTIGEN; HEAD; PROTEIN; P53; CLASSIFICATION; PROLIFERATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Wong, DTW Harvard Univ, Sch Dent Med, Dept Oral Med & Diagnost Sci, Div Oral Pathol,Lab Mol Pathol, 188 Longwood Ave, Boston, MA 02115 USA Harvard Univ 188 Longwood Ave Boston MA USA 02115 , MA 02115 USA
Citazione:
S. Shintani et al., "Reduction of p12(DOC-1) expression is a negative prognostic indicator in patients with surgically resected oral squamous cell carcinoma", CLIN CANC R, 7(9), 2001, pp. 2776-2782

Abstract

Purpose: p12(DOC-1) is a growth suppressor that negatively regulates cyclin-dependent kinase 2 (CDK2) activities. Expression of p12(DOC-1) is reducedand/or lost in tumor tissues. The purpose of this study is to correlate invivo the expression of p12(DOC-1) in oral cancer tissues by immunohistochemistry with clinical and pathological parameters. Experimental Design: Twenty-five cases of normal oral mucosa and 127 casesof oral squamous cell carcinomas were evaluated. Patients' charts were reviewed for clinical, pathological, and 10-year survival data. Because p12(DOC-1) is a growth suppressor and associates with CDK2, parallel immunostaining was done for proliferating cell nuclear antigen and CDK2 to evaluate cell proliferation and potential correlation with CDK2. Results: Our results showed that strong p12(DOC-1) staining was uniformly seen in normal oral mucosa. p12(DOC-1) staining was reduced or absent in 81cases (63.8%) of oral squamous cell carcinomas. Decreased p12(DOC-1) staining (< 25% of cells stained) correlated with tumor mode of invasion (P = 0.001) and higher proliferating cell nuclear antigen (P = 0.0028) and CDK2 (P= 0.0020) expression. Survival analysis showed significant correlation of low p12(DOC-1) expression with the risk of cervical lymph node metastasis (P = 0.001) and patients' 10-year survival status (P = 0.0214). Conclusions: These results allow us to conclude that reduction of P12(DOC-1) protein expression is a frequent event in oral cancers. Intratumor immunohistochemical evaluation of p12(DOC-1) expression can be an adjunctive prognostic indicator for patients with oral cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 22:29:02