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Titolo:
Comprehensive allelotyping of human intrahepatic cholangiocarcinoma
Autore:
Momoi, H; Okabe, H; Kamikawa, T; Satoh, S; Ikai, I; Yamamoto, M; Nakagawara, A; Shimahara, Y; Yamaoka, Y; Fukumoto, M;
Indirizzi:
Tohoku Univ, Inst Dev Aging & Canc, Dept Pathol, Aoba Ku, Sendai, Miyagi 9808575, Japan Tohoku Univ Sendai Miyagi Japan 9808575 Ku, Sendai, Miyagi 9808575, Japan Chiba Canc Ctr, Chiba 2600801, Japan Chiba Canc Ctr Chiba Japan 2600801Chiba Canc Ctr, Chiba 2600801, Japan Kyoto Univ, Grad Sch Med, Dept Surg Gastroenterol, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Surg Gastroenterol, Kyoto 6068507, Japan
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 9, volume: 7, anno: 2001,
pagine: 2648 - 2655
SICI:
1078-0432(200109)7:9<2648:CAOHIC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN HEPATOCELLULAR CARCINOMAS; E-CADHERIN GENE; HOMOZYGOUS DELETIONS; BLADDER-CANCER; FREQUENT LOSS; LUNG-CANCER; HETEROZYGOSITY; METHYLATION; TUMORS; MUTATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Fukumoto, M Tohoku Univ, Inst Dev Aging & Canc, Dept Pathol, Aoba Ku, 4-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan Tohoku Univ 4-1 Seiryo Machi Sendai Miyagi Japan 9808575 Japan
Citazione:
H. Momoi et al., "Comprehensive allelotyping of human intrahepatic cholangiocarcinoma", CLIN CANC R, 7(9), 2001, pp. 2648-2655

Abstract

We performed a genome-wide scan for loss of heterozygosity (LOH) in 22 intrahepatic cholangiocarcinoma (ICC) cases using 168 polymorphic microsatellite markers throughout all of the human chromosomes and 48 markers of which LOH is reportedly characteristic of hepatocellular carcinoma (HCC). Markerswith LOH in more than 30% of informative cases were observed at 21 loci. Among these, eight markers on 6q (three loci), 4q (two loci), 9q, 16q, and 17p shared high frequencies of LOH with HCC in our previous study. As for gross appearance, mass-forming type tumors showed higher frequency of LOH (P < 0.001) compared with other types. Compared by tumor size (less than or equal to5 cm versus >5 cm), number (multiple versus solitary), and the International Union Against Cancer TNM classification (stage IVB versus II-IVA), LOH was observed more frequently in advanced stages (P < 0.01, respectively). However, LOH frequency does not differ regardless of lymph node status (pN0 versus pN1). Frequent LOH on 1p36 including the p73 locus was noted in large tumors without lymph node metastasis. These suggest that ICC shares some common carcinogenic steps with HCC such as LOH of 4q and 6q and that inactivation of tumor suppressor genes on chromosome 1p36 contributes to progression of ICC but not to metastatic traits.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 00:31:57