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Titolo:
Genetic polymorphisms of adrenergic receptors
Autore:
Garland, EM; Biaggioni, I;
Indirizzi:
Vanderbilt Univ, Dept Med, Div Clin Pharmacol, Nashville, TN 37212 USA Vanderbilt Univ Nashville TN USA 37212 Pharmacol, Nashville, TN 37212 USA Vanderbilt Univ, Dept Pharmacol, Div Clin Pharmacol, Nashville, TN 37212 USA Vanderbilt Univ Nashville TN USA 37212 Pharmacol, Nashville, TN 37212 USA
Titolo Testata:
CLINICAL AUTONOMIC RESEARCH
fascicolo: 2, volume: 11, anno: 2001,
pagine: 67 - 78
SICI:
0959-9851(200104)11:2<67:GPOAR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BETA(2)-ADRENERGIC RECEPTOR; SINGLE-NUCLEOTIDE POLYMORPHISMS; IDIOPATHIC DILATED CARDIOMYOPATHY; ACTIVATED PROTEIN-KINASE; BODY-MASS INDEX; BETA(3)-ADRENERGIC RECEPTOR; ESSENTIAL-HYPERTENSION; BLOOD-PRESSURE; BETA-2-ADRENERGIC RECEPTOR; DIABETES-MELLITUS;
Keywords:
adrenergic; receptors; polymorphism; alleles; genotype;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
99
Recensione:
Indirizzi per estratti:
Indirizzo: Biaggioni, I Vanderbilt Univ, Dept Med, Div Clin Pharmacol, 1500 21st Ave S,Suite 3500,Nashville, TN 37212 USA Vanderbilt Univ 1500 21st Ave S,Suite 3500 Nashville TN USA 37212
Citazione:
E.M. Garland e I. Biaggioni, "Genetic polymorphisms of adrenergic receptors", CLIN AUTON, 11(2), 2001, pp. 67-78

Abstract

Recent advances in molecular biology have enhanced the understanding of adrenergic receptors. They have allowed the characterization of the several subtypes of adrenergic receptors expressed and have expanded the research about the potential physiologic functions they mediate. Furthermore, variant forms, or polymorphisms, of the genes that code for these receptors are being identified. These genetic variants may or may not result in functional differences in the receptors they encode. There is obvious interest in determining the physiologic and clinical relevance of these polymorphisms. The purpose of this review is to describe these polymorphisms and the often contradictory literature pertaining to their clinical significance. Progress inthis area is being made at a rapid pace. As the allele-disease relations become less equivocal, it might be possible to predict individual differences in susceptibility to a disease, disease prognosis, and response to treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 10:21:52