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Titolo:
Autonomic dysfunction in Lambert-Eaton myasthenic syndrome
Autore:
Waterman, SA;
Indirizzi:
Flinders Med Ctr, Dept Immunol Allergy & Arthrit, Bedford Pk, SA 5042, Australia Flinders Med Ctr Bedford Pk SA Australia 5042 ford Pk, SA 5042, Australia
Titolo Testata:
CLINICAL AUTONOMIC RESEARCH
fascicolo: 3, volume: 11, anno: 2001,
pagine: 145 - 154
SICI:
0959-9851(200106)11:3<145:ADILMS>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM-CHANNEL AUTOANTIBODIES; CONTROLLING ACETYLCHOLINE-RELEASE; MEMBRANE ACTIVE ZONES; MOTOR-NERVE TERMINALS; PARANEOPLASTIC SYNDROMES; TRANSMITTER RELEASE; SYNDROME ANTIBODIES; MOUSE; IGG; CANCER;
Keywords:
autoantibody; calcium channel; enteric nervous system; sympathetic; parasympathetic; paraneoplastic; transmitter release;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Waterman, SA Flinders Med Ctr, Dept Immunol Allergy & Arthrit, Bedford Pk,SA 5042, Australia Flinders Med Ctr Bedford Pk SA Australia 5042 042, Australia
Citazione:
S.A. Waterman, "Autonomic dysfunction in Lambert-Eaton myasthenic syndrome", CLIN AUTON, 11(3), 2001, pp. 145-154

Abstract

Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder characterized by muscle weakness and autonomic dysfunction. Recent ex vivo and in vitro studies demonstrate that autoantibodies to the P/Q-subtype of voltage-gated calcium channel inhibit transmitter release from parasympathetic, sympathetic, and enteric neurons, a mechanism likely to underlie the widespread autonomic dysfunction in LEMS. This review summarizes clinical studies characterizing the autonomic symptoms and signs in LEMS and the effectiveness of treatment in alleviating these symptoms. Serological assays and in vitro pharmacologic and electrophysiologic studies are also discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 21:50:47