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Titolo:
Factors related to allergic sensitization to aeroallergens in a cross-sectional study in adults: The Copenhagen Allergy Study
Autore:
Linneberg, A; Nielsen, NH; Madsen, F; Frolund, L; Dirksen, A; Jorgensen, T;
Indirizzi:
Glostrup Cty Hosp, Ctr Prevent Med, Dept Internal Med M, DK-2600 Glostrup,Denmark Glostrup Cty Hosp Glostrup Denmark DK-2600 d M, DK-2600 Glostrup,Denmark Gentofte Univ Hosp, Dept Dermatol, Gentofte, Denmark Gentofte Univ Hosp Gentofte Denmark p, Dept Dermatol, Gentofte, Denmark Frederiksberg Univ Hosp, Dept Internal Med B, Frederiksberg, Denmark Frederiksberg Univ Hosp Frederiksberg Denmark B, Frederiksberg, Denmark Gentofte Univ Hosp, Dept Resp Med Y, Gentofte, Denmark Gentofte Univ HospGentofte Denmark Dept Resp Med Y, Gentofte, Denmark
Titolo Testata:
CLINICAL AND EXPERIMENTAL ALLERGY
fascicolo: 9, volume: 31, anno: 2001,
pagine: 1409 - 1417
SICI:
0954-7894(200109)31:9<1409:FRTAST>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKIN-TEST REACTIVITY; BODY-MASS INDEX; COMMUNITY-BASED POPULATION; RESPIRATORY HEALTH SURVEY; TOTAL SERUM IGE; HAY-FEVER; INCREASING PREVALENCE; ASTHMA; ATOPY; SMOKING;
Keywords:
adult; alcohol consumption; body mass index; respiratory hypersensitivity; risk factors; skin prick test; smoking; specific IgE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Linneberg, A Glostrup Cty Hosp, Ctr Prevent Med, Dept Internal Med M, 57 Ndr Ringvej,Entrance 8,7th Floor, DK-2600 Glostrup, Denmark Glostrup Cty Hosp 57 Ndr Ringvej,Entrance 8,7th Floor Glostrup Denmark DK-2600
Citazione:
A. Linneberg et al., "Factors related to allergic sensitization to aeroallergens in a cross-sectional study in adults: The Copenhagen Allergy Study", CLIN EXP AL, 31(9), 2001, pp. 1409-1417

Abstract

Background The factors underlying recent increases in the prevalence of respiratory allergy are largely unknown. Objective To assess the association between allergic sensitization and several lifestyle/environmental factors. Methods A cross-sectional population-based study of 15-69-year-olds in Copenhagen was carried out in 1990. The participation rate was 77.5% (1112/1435). Different lifestyle/ environmental factors (explanatory variables) weredefined based on questionnaire data. Dependent (outcome) variables were skin prick test (SPT) positivity or specific IgE positivity to common aeroallergens. Explanatory variables associated with outcome in univariate analysis (P < 0.25) were selected for multivariate analysis. Subsequently, a finalmodel for each dependent variable was obtained by stepwise regression analysis (cutoff for entry/removal of variables: P < 0.1). Results Male sex, young age, low number of siblings, a positive family history of hay fever and never smoking, were independently associated with both SPT positivity and specific IgE positivity. Furthermore, SPT positivity was positively associated with alcohol consumption (dose-response relationship only), and negatively associated with previous keeping of a dog in the household. The association between alcohol consumption and SPT positivity was mainly due to the consumption of wine and remained after adjustment for educational level. Specific IgE positivity was furthermore associated with body mass index with no apparent dose-response relationship. Conclusion Being mate, young age, a positive family history of hayfever, low number of siblings and never smoking, were independently associated withallergic sensitization. In addition, the results indicated a possible relationship of alcohol consumption, body mass index and previous keeping of a dog in the household to allergic sensitization. There is a need for prospective studies of risk factors for respiratory allergy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 10:14:52