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Titolo:
Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure
Autore:
Nagaya, N; Uematsu, M; Kojima, M; Ikeda, Y; Yoshihara, F; Shimizu, W; Hosoda, H; Hirota, Y; Ishida, H; Mori, H; Kangawa, K;
Indirizzi:
Natl Cardiovasc Ctr, Dept Internal Med, Suita, Osaka 5658565, Japan Natl Cardiovasc Ctr Suita Osaka Japan 5658565 Suita, Osaka 5658565, Japan Osaka Seamens Insurance Hosp, Dept Internal Med, Osaka, Japan Osaka Seamens Insurance Hosp Osaka Japan ept Internal Med, Osaka, Japan Natl Cardiovasc Ctr, Res Inst, Dept Biochem, Osaka, Japan Natl Cardiovasc Ctr Osaka Japan r, Res Inst, Dept Biochem, Osaka, Japan Natl Cardiovasc Ctr, Dept Pathol, Osaka, Japan Natl Cardiovasc Ctr OsakaJapan rdiovasc Ctr, Dept Pathol, Osaka, Japan Natl Cardiovasc Ctr, Res Inst, Dept Cardiac Physiol, Osaka, Japan Natl Cardiovasc Ctr Osaka Japan nst, Dept Cardiac Physiol, Osaka, Japan Tokai Univ, Dept Physiol, Kanagawa 2591100, Japan Tokai Univ Kanagawa Japan 2591100 Dept Physiol, Kanagawa 2591100, Japan Tokai Univ, Res Ctr Genet Engn & Cell Transplantat, Kanagawa 2591100, Japan Tokai Univ Kanagawa Japan 2591100 Transplantat, Kanagawa 2591100, Japan
Titolo Testata:
CIRCULATION
fascicolo: 12, volume: 104, anno: 2001,
pagine: 1430 - 1435
SICI:
0009-7322(20010918)104:12<1430:CAOGIL>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOMBINANT GROWTH-HORMONE; DILATED CARDIOMYOPATHY; MYOCARDIAL-INFARCTION; BODY-COMPOSITION; DOUBLE-BLIND; FACTOR-I; DEFICIENCY; ACTIVATION; MYOCYTES; PEPTIDE;
Keywords:
heart failure; hormones; growth substances; nutrition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Nagaya, N Natl Cardiovasc Ctr, Dept Internal Med, 5-7-1 Fujishirodai, Suita, Osaka 5658565, Japan Natl Cardiovasc Ctr 5-7-1 Fujishirodai Suita Osaka Japan 5658565
Citazione:
N. Nagaya et al., "Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure", CIRCULATION, 104(12), 2001, pp. 1430-1435

Abstract

Background-Ghrelin is a novel growth hormone (GH)-releasing peptide that may also induce vasodilation and stimulate feeding through GH-independent mechanisms. We investigated whether ghrelin improves left ventricular (LV) dysfunction and attenuates cardiac cachexia in rats with chronic heart failure (CHF). Methods and Results-Ligation of the left coronary artery or sham operationwas performed; 4 weeks after surgery, rat ghrelin (100 mug/kg SC BID) or saline was administered for 3 weeks. Echocardiography and cardiac catheterization were performed. Serum GH and insulin-like growth factor-1 were significantly higher in both CHF and sham rats treated with ghrelin than in thosegiven placebo (P <0.05 for both). CHF rats given placebo showed an impaired increase in body weight compared with sham rats given placebo (P <0.05). CHF rats treated with ghrelin, however, showed a significantly greater increase in body weight than those given placebo (+ 10% versus +3%, P <0.05). They showed significantly higher cardiac output (315 +/- 49 versus 266 +/- 31 mL (.) min(-1) (.) kg(-1), P <0.05) and LV dP/dt(max) (5738 +/- 908 versus 4363 +/- 973 mm Hg/s, P <0.05) than CHF rats given placebo. Ghrelin increased diastolic thickness of the noninfarcted posterior wall, inhibited LV enlargement, and increased LV fractional shortening in CHF rats (from 15 +/-3% to 19 +/-3%, P <0.05). Conclusions-Chronic subcutaneous administration of ghrelin improved LV dysfunction and attenuated the development of LV remodeling and cardiac cachexia in rats with CHF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 23:55:39