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Titolo:
Sweetener preference of C57BL/6ByJ and 129P3/J mice
Autore:
Bachmanov, AA; Tordoff, MG; Beauchamp, GK;
Indirizzi:
Monell Chem Senses Ctr, Philadelphia, PA 19104 USA Monell Chem Senses CtrPhiladelphia PA USA 19104 iladelphia, PA 19104 USA
Titolo Testata:
CHEMICAL SENSES
fascicolo: 7, volume: 26, anno: 2001,
pagine: 905 - 913
SICI:
0379-864X(200109)26:7<905:SPOCA1>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
3 DIFFERENT STRAINS; GUSTATORY RESPONSES; SWEETNESS RECEPTOR; SODIUM-CHLORIDE; INBRED STRAINS; TASTE; CONSUMPTION; SACCHARIN; GENETICS; SUCROSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Bachmanov, AA Monell Chem Senses Ctr, 3500 Market St, Philadelphia, PA 19104 USA Monell Chem Senses Ctr 3500 Market St Philadelphia PA USA 19104
Citazione:
A.A. Bachmanov et al., "Sweetener preference of C57BL/6ByJ and 129P3/J mice", CHEM SENSE, 26(7), 2001, pp. 905-913

Abstract

Previous studies have shown large differences in taste responses to several sweeteners between mice of the C57BL/6ByJ (B6) and 129P3/J (129) inbred strains. The goal of this study was to compare behavioral responses of B6 and 129 mice to a wider variety of sweeteners. Seventeen sweeteners were tested using two-bottle preference tests with water. Three main patterns of strain differences were evident. First, sucrose, maltose, saccharin, acesulfame-K, sucralose and SC-45647 were preferred by both strains, but the B6 micehad lower preference thresholds and higher solution intakes. Second, the amino acids D-phenylalanine, D-tryptophan, L-proline and glycine were highlypreferred by B6 mice, but not by 129 mice. Third, glycyrrhizic acid, neohesperidin dihydrochalcone, thaumatin and cyclamate did not evoke strong preferences in either strain. Aspartame was neutral to all 129 and some B6 mice, but other B6 mice strongly preferred it. Thus, compared with the 129 micethe B6 mice had higher preferences for sugars, sweet tasting amino acids and several but not all non-caloric sweeteners. Glycyrrhizic acid, neohesperidin, thaumatin and cyclamate are not palatable to B6 or 129 mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 05:39:24