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Titolo:
Arginase expression in peritoneal macrophages and increase in circulating polyamine levels in mice infected with Schistosoma mansoni
Autore:
Abdallahi, OMS; Bensalem, H; Augier, R; Diagana, M; De Reggi, M; Gharib, B;
Indirizzi:
INSERM, U399, F-13385 Marseille 5, France INSERM Marseille France 5INSERM, U399, F-13385 Marseille 5, France CNRS, Neurobiol Lab, Marseille, France CNRS Marseille FranceCNRS, Neurobiol Lab, Marseille, France
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 9, volume: 58, anno: 2001,
pagine: 1350 - 1357
SICI:
1420-682X(200108)58:9<1350:AEIPMA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; MURINE MACROPHAGES; ORNITHINE DECARBOXYLASE; LEISHMANIA-DONOVANI; TRYPANOSOMA-CRUZI; INTERFERON-GAMMA; L-ARGININE; IN-VIVO; LIPOPOLYSACCHARIDE; BIOSYNTHESIS;
Keywords:
arginase; NO synthase; polyamine; infectious disease; schistosomiasis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Gharib, B INSERM, U399, 27 Blvd Jean Moulin, F-13385 Marseille 5, France INSERM 27 Blvd Jean Moulin Marseille France 5 rseille 5, France
Citazione:
O.M.S. Abdallahi et al., "Arginase expression in peritoneal macrophages and increase in circulating polyamine levels in mice infected with Schistosoma mansoni", CELL MOL L, 58(9), 2001, pp. 1350-1357

Abstract

We investigated the nitric oxide (NO) synthase and arginase pathways in resident peritoneal macrophages of mice infected with the tropical parasite Schistosoma mansoni. The two enzymes may have opposite effects, insofar as NO may be involved in the killing of the parasite whereas arginase may stimulate parasite growth via polyamine synthesis. We determined the effects of the infection on the expression and activity of the two enzymes in macrophages, before and after cytokine activation. Cells from infected mice expressed the hepatic type I arginase, whereas in control cells, the enzyme was expressed only after cytokine activation, as were NO synthase II and type II arginase in both groups of cells. Moreover, we found that in infected mice,arginase expression in macrophages was associated with a ten fold increasein the concentration of circulating ornithine-derived polyamines. This maybe of pathological importance, since parasitic helminths are though to be dependent on their hosts for the uptake and interconversion of polyamines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 05:33:27