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Titolo:
Peroxisomes in the apocrine sweat glands of the human axilla and their putative role in pheromone production
Autore:
Rothardt, G; Beier, K;
Indirizzi:
Anat Inst, CH-4056 Basel, Switzerland Anat Inst Basel Switzerland CH-4056 nat Inst, CH-4056 Basel, Switzerland
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 9, volume: 58, anno: 2001,
pagine: 1344 - 1349
SICI:
1420-682X(200108)58:9<1344:PITASG>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN VOMERONASAL ORGAN; CHOLESTEROL-BIOSYNTHESIS; SEBACEOUS GLANDS; BETA-OXIDATION; MICROBODIES PEROXISOMES; MEVALONATE KINASE; DEFICIENCY; ENZYMES; COMPARTMENTALIZATION; PROLIFERATION;
Keywords:
peroxisome; pheromone; axillary apocrine gland; cholesterol biosynthesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Beier, K Anat Inst, Pestalozzistr 20, CH-4056 Basel, Switzerland Anat InstPestalozzistr 20 Basel Switzerland CH-4056 Switzerland
Citazione:
G. Rothardt e K. Beier, "Peroxisomes in the apocrine sweat glands of the human axilla and their putative role in pheromone production", CELL MOL L, 58(9), 2001, pp. 1344-1349

Abstract

The products of the human apocrine axillary glands contain volatile steroids which act as pheromones, The steroidal structure of these pheromones implies that the axillary glands should be able to synthesize cholesterol which is the essential precursor of these molecules. Since important steps in cholesterol synthesis are localized within peroxisomes, we investigated the occurrence and the putative role of peroxisomes in the axillary glands at protein and mRNA levels by immunocytochemistry, Western blotting, and RT-PCR. Numerous peroxisomes were localized in the cells of the apocrine glands by immunocytochemistry, and the presence of catalase was confirmed by Western blotting and RT-PCR. Additionally, RT-PCR revealed the presence of mRNAs of two peroxisome-associated enzymes of the cholesterol biosynthetic pathway, mevalonate kinase and farnesyl diphosphate synthase, The results suggestthat the peroxisomes in the human apocrine axillary glands may play a pivotal role in the biosynthesis of pheromones.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 10:32:05