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Titolo:
Potent induction of wild-type p53-dependent transcription in tumour cells by a synthetic inhibitor of cyclin-dependent kinases
Autore:
Kotala, V; Uldrijan, S; Horky, M; Trbusek, M; Strnad, M; Vojtesek, B;
Indirizzi:
Masaryk Mem Canc Inst, Dept Expt Oncol, Brno 65653, Czech Republic MasarykMem Canc Inst Brno Czech Republic 65653 no 65653, Czech Republic Res Inst Child Hlth, Dept Biochem & Mol Genet, Brno 66089, Czech Republic Res Inst Child Hlth Brno Czech Republic 66089 Brno 66089, Czech Republic Palacky Univ, Lab Growth Regulators, Olomouc 78371, Czech Republic PalackyUniv Olomouc Czech Republic 78371 Olomouc 78371, Czech Republic
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 9, volume: 58, anno: 2001,
pagine: 1333 - 1339
SICI:
1420-682X(200108)58:9<1333:PIOWPT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODIES; P53; PROTEIN; BINDING;
Keywords:
roscovitine; p53; p21; transcriptional activity; tumour cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Vojtesek, B Masaryk Mem Canc Inst, Dept Expt Oncol, Zluty Kopec 7, Brno 65653, Czech Republic Masaryk Mem Canc Inst Zluty Kopec 7 Brno Czech Republic 65653
Citazione:
V. Kotala et al., "Potent induction of wild-type p53-dependent transcription in tumour cells by a synthetic inhibitor of cyclin-dependent kinases", CELL MOL L, 58(9), 2001, pp. 1333-1339

Abstract

Activation of the p53 tumour suppressor protein by distinct forms of stress leads to inhibition of cellular proliferation by inducing cell cycle arrest or apoptosis. The cyclin-dependent kinase inhibitor roscovitine has beenshown to induce nuclear accumulation of wild-type p53 in human untransformed and tumour-derived cells. We analyzed the response of different human tumour cell lines to roscovitine treatment with respect to their p53 status. Striking induction of wild-type p53 protein and dramatic enhancement of p53-dependent transcription, coinciding with p21(WAF1) induction, was observedin wildtype, but not mutant, p53-bearing tumour cells after treatment withroscovitine. The transcriptional activity of p53 was substantially higher in roscovitine-treated cells than in cells irradiated with ultraviolet C orionizing radiation, even though all these agents induced a similar amount of p53 accumulation. These results highlight the therapeutic potential of roscovitine as an anticancer drug, especially in tumours retaining a functional wild-type p53 pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 18:46:03