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Titolo:
Pre-menstrual steroids
Autore:
Smith, SS;
Indirizzi:
SUNY Hlth Sci Ctr, Dept Physiol & Pharmacol, Brooklyn, NY 11203 USA SUNY Hlth Sci Ctr Brooklyn NY USA 11203 Pharmacol, Brooklyn, NY 11203 USA
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 9, volume: 58, anno: 2001,
pagine: 1263 - 1275
SICI:
1420-682X(200108)58:9<1263:PS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREMENSTRUAL DYSPHORIC DISORDER; CHRONIC NEUROSTEROID TREATMENT; GABA(A) RECEPTOR SUBUNIT; METHYL-D-ASPARTATE; AMINOBUTYRIC ACID(A) RECEPTORS; SEROTONIN REUPTAKE INHIBITORS; DEHYDROEPIANDROSTERONE-SULFATE; PREGNENOLONE SULFATE; ALPHA-4 SUBUNIT; PROGESTERONE METABOLITES;
Keywords:
allopregnanolone; withdrawal; alpha 4 subunit; GABA(A) receptor; pre-menstrual syndrome; PMS; premenstrual dysphoric disorder; PMDD; hippocampus; rat;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
122
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, SS SUNY Hlth Sci Ctr, Dept Physiol & Pharmacol, 450 Clarkson Ave, Brooklyn, NY 11203 USA SUNY Hlth Sci Ctr 450 Clarkson Ave Brooklyn NY USA 11203 203 USA
Citazione:
S.S. Smith, "Pre-menstrual steroids", CELL MOL L, 58(9), 2001, pp. 1263-1275

Abstract

A number of steroid hormones and their metabolites fluctuate in the circulation across the human menstrual cycle. In addition to their classic actions on the hypothalamo-pituitary-gonadal axis, many of these hormones act as 'neuroactive steroids' to alter the function of neurotransmitters, such as GABA, within central nervous system circuits. Clinically, these steroids are important because they have not only acute but also long-term effects, and 'withdrawal' properties. This review discusses the effects of steroids such as 3 alpha -OH-5 alpha -pregnan-20-one (3 alpha ,5 alpha -THP or allopregnanolone) which alter GABA function in distinct ways dependent upon the time course of exposure, to either enhance or decrease inhibition in the brain. These effects are discussed in light of recent clinical findings which seek to further characterize the steroid milieu which underlies pre-menstrual dysphoria.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:39:38