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Titolo:
Tetraspanins
Autore:
Boucheix, C; Rubinstein, E;
Indirizzi:
Hop Paul Brousse, Inst Andre Lwoff, INSERM, U268, F-94807 Villejuif, France Hop Paul Brousse Villejuif France F-94807 268, F-94807 Villejuif, France
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 9, volume: 58, anno: 2001,
pagine: 1189 - 1205
SICI:
1420-682X(200108)58:9<1189:T>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
METASTASIS-SUPPRESSOR GENE; T-CELL ACTIVATION; ACUTE LYMPHOBLASTIC-LEUKEMIA; HUMAN B-LYMPHOCYTES; HEPATITIS-C VIRUS; MHC CLASS-II; TRANSMEMBRANE-4 SUPERFAMILY MOLECULE; SIGNAL-TRANSDUCTION COMPLEX; INTEGRIN-ASSOCIATED PROTEIN; DIPHTHERIA-TOXIN RECEPTOR;
Keywords:
tetraspanin; integrin; cancer; cell migration; reproduction; fusion;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
189
Recensione:
Indirizzi per estratti:
Indirizzo: Boucheix, C Hop Paul Brousse, Inst Andre Lwoff, INSERM, U268, F-94807 Villejuif, France Hop Paul Brousse Villejuif France F-94807 Villejuif, France
Citazione:
C. Boucheix e E. Rubinstein, "Tetraspanins", CELL MOL L, 58(9), 2001, pp. 1189-1205

Abstract

The first tetraspanins were discovered on surface of human leucocytes, butit was rapidly demonstrated that they had a wider tissue expression. Twenty-six molecules display sufficient homology to belong to the same superfamily. Their function is not precisely known, but data coming from biochemicalstudies or knockout mice suggest that they play a major role in membrane biology. One of their outstanding properties is their ability to form a network of multimolecular complexes, the 'tetraspanin web', in which integrins are included. The structure of these complexes is under investigation, but some of the rules that govern their organization have already been unraveled. The challenge is to determine how the organization of the 'tetraspanin web' modifies the function of its constitutive molecules and consequently influences cellular behaviour. The implications may be considerable for the understanding of basic cellular processes such as migration and also of diseases related to loss or mutation of a single tetraspanin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:33:49