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Titolo:
Healing response to the Clamshell device for closure of intracardiac defects in humans
Autore:
Kreutzer, J; Ryan, CA; Gauvreau, K; Van Praagh, R; Anderson, JM; Jenkins, KJ;
Indirizzi:
Univ Penn, Div Cardiol, Dept Pediat, Philadelphia, PA 19104 USA Univ PennPhiladelphia PA USA 19104 pt Pediat, Philadelphia, PA 19104 USA NMT Med Inc, Boston, MA USA NMT Med Inc Boston MA USANMT Med Inc, Boston, MA USA Harvard Univ, Sch Med, Dept Pediat, Childrens Hosp,Dept Cardiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Hosp,Dept Cardiol, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Pathol, Childrens Hosp, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ol, Childrens Hosp, Boston, MA 02115 USA Case Western Reserve Univ, Univ Hosp, Dept Pathol, Cleveland, OH 44106 USACase Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA
Titolo Testata:
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
fascicolo: 1, volume: 54, anno: 2001,
pagine: 101 - 111
SICI:
1522-1946(200109)54:1<101:HRTTCD>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATRIAL SEPTAL-DEFECT; TRANSCATHETER CLOSURE; UMBRELLA CLOSURE; OCCLUSION; OCCLUDER; HEART;
Keywords:
cardiac catheterization; atrial septal defect; histopathology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Kreutzer, J Univ Penn, Div Cardiol, Dept Pediat, 34th St & Civic Ctr Blvd,Philadelphia, PA 19104 USA Univ Penn 34th St & Civic Ctr Blvd PhiladelphiaPA USA 19104 A
Citazione:
J. Kreutzer et al., "Healing response to the Clamshell device for closure of intracardiac defects in humans", CATHET C IN, 54(1), 2001, pp. 101-111

Abstract

The healing response to intracardiac devices in humans is largely unknown. During regulatory trials using the Clamshell device in over 800 patients, attempts were made to perform histopathological evaluation of all explanteddevices. We reviewed all those with complete histopathological examination(n = 12) from Fontan baffles (n = 4), ventricular septal defects (n = 2), and atrial septal defects (ASD; n = 6), explanted at 2.7 months to 3.6 years (median, 1.6 years), at autopsy (n = 1) or surgery (n = 11), performed for residual defects (n = 5), atrial masses (n = 3), or Fontan revision (n = 3). All but one were nearly (n = 3) or completely (n = 8) covered by pseudointima, composed of fibroelastic tissue, predominantly collagen, with focalforeign body reaction in contact with fabric, without acute inflammation or infection. Atrial masses of granulation tissue were present in three cases (ASD), opposite to protruding fractured arms. No associations were identified between coverage and closure status, position, arm fractures, or implant period. In conclusion, the healing response to transcatheter Clamshell implantation in humans is characterized by a relatively rapid development ofa nonthrombotic pseudointima composed of fibroelastic tissue with minimal foreign body reaction. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 16:50:16