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Titolo:
Incremental doses of intracoronary adenosine for the assessment of coronary velocity reserve for clinical decision making
Autore:
Di Segni, E; Higano, ST; Rihal, CS; Holmes, DR; Lennon, R; Lerman, A;
Indirizzi:
Mayo Clin & Mayo Fdn, Div Cardiovasc Dis, Ctr Coronary Physiol & Imaging, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 ging, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Dept Internal Med, Rochester, MN 55905 USA Mayo Clin& Mayo Fdn Rochester MN USA 55905 Med, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Biostat Sect, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Sect, Rochester, MN 55905 USA
Titolo Testata:
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
fascicolo: 1, volume: 54, anno: 2001,
pagine: 34 - 40
SICI:
1522-1946(200109)54:1<34:IDOIAF>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERY FLOW VELOCITY; DOPPLER GUIDE-WIRE; VASODILATOR RESERVE; ANGIOPLASTY; DISEASE; ANGIOGRAPHY; STENOSES; HUMANS; TRIAL;
Keywords:
coronary flow reserve; Doppler;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Lerman, A Mayo Clin & Mayo Fdn, Div Cardiovasc Dis, Ctr Coronary Physiol &Imaging, 200 1st St SW,MB 4-523, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn 200 1st St SW,MB 4-523 Rochester MN USA 55905
Citazione:
E. Di Segni et al., "Incremental doses of intracoronary adenosine for the assessment of coronary velocity reserve for clinical decision making", CATHET C IN, 54(1), 2001, pp. 34-40

Abstract

Achievement of maximal vasodilatation of the coronary microcirculation is a prerequisite for the measurement of coronary flow reserve (CFR). The present study was designed to address the hypothesis that intracoronary adenosine yields more complete vasodilation of the coronary microcirculation when incremental doses are used, resulting in higher and more accurate coronary flow reserve measurements. Four hundred and fifty-seven patients were divided in two groups; group I (319 patients) comprised patients without angiographic evidence of significant coronary artery disease, while group II (138 patients) comprised patients with intermediate coronary stenoses (between 40% and 70% diameter stenosis). Coronary velocity reserve (CVR, a surrogate measurement for CFR) was measured during cardiac catheterization using a Doppler-tipped guidewire. Incremental doses of intracoronary adenosine (12 to54 mug for the left coronary artery and 6 to 42 mug for the right coronaryartery) were administered. There was a significant difference between the initial dose of adenosine and the subsequent incremental doses. Of a total of 479 observations, only 192 (40%) had the maximal CVR value at the first dose. Thirty-nine percent of the patients in group I and 27% in group II with an initial CVR value < 2.5 increased CVR to greater than or equal to 2.5with incremental doses of adenosine. This study suggests that incremental doses of adenosine should be used to achieve maximal CVR for the assessmentof the functional significance of coronary lesions. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:04:57