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Titolo:
12-lipoxygenase inhibition induced apoptosis in human gastric cancer cells
Autore:
Wong, BCY; Wang, WP; Cho, CH; Fan, XM; Lin, MCM; Kung, HF; Lam, SK;
Indirizzi:
Univ Hong Kong, Dept Med, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Univ Hong Kong, Dept Pharmacol, Hong Kong, Hong Kong, Peoples R China UnivHong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Univ Hong Kong, Inst Mol Biol, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China
Titolo Testata:
CARCINOGENESIS
fascicolo: 9, volume: 22, anno: 2001,
pagine: 1349 - 1354
SICI:
0143-3334(200109)22:9<1349:1IIAIH>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET-TYPE 12-LIPOXYGENASE; EPIDERMAL GROWTH-FACTOR; ARACHIDONATE 12-LIPOXYGENASE; LIPOXYGENASE METABOLITE; CYTOCHROME-C; EXPRESSION; LINES; RELEASE; BCL-2; P53;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Wong, BCY Univ Hong Kong, Dept Med, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China les R China
Citazione:
B.C.Y. Wong et al., "12-lipoxygenase inhibition induced apoptosis in human gastric cancer cells", CARCINOGENE, 22(9), 2001, pp. 1349-1354

Abstract

Arachidonic acid release from membrane phospholipids is essential for tumour cell proliferation. Lipoxygenases constitute a pathway for arachidonate metabolism. The present study investigated the expression of 12-lipoxygenase and its effect on cell proliferation as well as survival in two human gastric cancer cell lines (AGS and MKN-28). RT-PCR and western blots, respectively, showed 12-LOX mRNA and protein expression in both AGS and MKN-28 celllines. Treatment with a 12-LOX inhibitor, baicalein, significantly inhibited cancer cell proliferation, but a metabolite of 12-LOX activity, 12 hydroxyeicosatetraenoic acid (12-HETE) reversed baicalein-induced growth inhibition. Furthermore, the blockade of the 12-LOX pathway through a 12-LOX inhibitor and antisense induced apoptosis of gastric cancer cell lines. The biochemical characteristics of apoptosis were p53-independent combined with a decrease in bcl-2 expression. Caspase-7 was proteolytically activated and responsible for the apoptosis execution.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:02:00