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Titolo:
Inhibition of serotonin reuptake by antidepressants and upper gastrointestinal bleeding in elderly patients: retrospective cohort study
Autore:
van Walraven, C; Mamdani, MM; Wells, PS; Williams, JI;
Indirizzi:
Ottawa Hosp, Ottawa Hlth Res Inst, Clin Epidemiol Unit, Ottawa, ON K1Y 4E9, Canada Ottawa Hosp Ottawa ON Canada K1Y 4E9 iol Unit, Ottawa, ON K1Y 4E9, Canada Inst Clin Evaluat Sci, Toronto, ON M4N 3M5, Canada Inst Clin Evaluat Sci Toronto ON Canada M4N 3M5 ronto, ON M4N 3M5, Canada Toronto Rehabil Inst, Toronto, ON M5G 2A2, Canada Toronto Rehabil Inst Toronto ON Canada M5G 2A2 oronto, ON M5G 2A2, Canada
Titolo Testata:
BRITISH MEDICAL JOURNAL
fascicolo: 7314, volume: 323, anno: 2001,
pagine: 655 - 658
SICI:
0959-535X(20010922)323:7314<655:IOSRBA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLUOXETINE; HEMORRHAGE; RISK; ASSOCIATION; DRUGS; TIME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: van Walraven, C Ottawa Hosp, Ottawa Hlth Res Inst, Clin Epidemiol Unit, Civ Campus, Ottawa, ON K1Y 4E9, Canada Ottawa Hosp Civ Campus Ottawa ON Canada K1Y 4E9 E9, Canada
Citazione:
C. van Walraven et al., "Inhibition of serotonin reuptake by antidepressants and upper gastrointestinal bleeding in elderly patients: retrospective cohort study", BR MED J, 323(7314), 2001, pp. 655-658

Abstract

Objectives To determine the association between inhibition of serotonin reuptake by antidepressants and upper gastrointestinal bleeding. Design Retrospective cohort study from population based databases. Setting Ontario, Canada. Participants 317 824 elderly people observed for more than 130 000 person years. The patients started taking an antidepressant between 1992 and 1998 and were grouped by how much the drug inhibited serotonin reuptake. Patients were observed until they stopped the drug, had an upper gastrointestinal bleed, or died or the study ended. Main outcome measure Admission to hospital for acute upper gastrointestinal bleeding. Results Overall, 974 bleeds were observed, with an overall bleeding rate of 7.3 per 1000 person years. After controlling for age or previous gastrointestinal bleeding, the risk of bleeding significantly increased by 10.7% and 9.8%, respectively, with increasing inhibition of serotonin reuptake. Absolute differences in bleeding between antidepressant groups were greatest for octogenarians (low inhibition of serotonin reuptake, 10.6 bleeds/1000 person years v high inhibition of serotonin reuptake, 14.7 bleeds/1000 personyears; number needed to harm 244) and those with previous upper gastrointestinal bleeding (low, 28.6 bleeds/1000 person years v high, 40.3 bleeds/1000 person years; number needed to harm 85). Conclusions After age or previous upper gastrointestinal bleeding were controlled for, antidepressants with high inhibition of serotonin reuptake increased the risk of upper gastrointestinal bleeding. These increases are clinically important for elderly patients and those with previous gastrointestinal bleeding.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:55:28