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Titolo:
Comparison of clozapine and haloperidol on some autonomic and psychomotor functions, and on serum prolactin concentration, in healthy subjects
Autore:
Pretorius, JL; Phillips, M; Langley, RW; Szabadi, E; Bradshaw, CM;
Indirizzi:
Univ Nottingham Hosp, Queens Med Ctr, Div Psychiat, Nottingham NG7 2UH, England Univ Nottingham Hosp Nottingham England NG7 2UH tingham NG7 2UH, England
Titolo Testata:
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
fascicolo: 3, volume: 52, anno: 2001,
pagine: 322 - 326
SICI:
0306-5251(200109)52:3<322:COCAHO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHIBITION; VOLUNTEERS; DRUGS;
Keywords:
cardiovascular functions; clozapine; critical flicker fusion frequency; haloperidol; prolactin; pupil; salivation; sedation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Szabadi, E Univ Nottingham, Queens Med Ctr, Div Psychiat, Psychopharmacol Sect, Nottingham NG7 2UH, England Univ Nottingham Nottingham England NG7 2UH m NG7 2UH, England
Citazione:
J.L. Pretorius et al., "Comparison of clozapine and haloperidol on some autonomic and psychomotor functions, and on serum prolactin concentration, in healthy subjects", BR J CL PH, 52(3), 2001, pp. 322-326

Abstract

Aims To compare the autonomic, neuroendocrine and psychomotor effects of single doses of the 'atypical' antipsychotic clozapine and the 'classical' antipsychotic haloperidol, in healthy male volunteers. Methods Clozapine (50 mg), haloperidol (3 mg) and placebo were administered to 12 healthy male volunteers at weekly intervals, according to a balanced double-blind design. Resting pupil diameter, salivary output, heart rate,blood pressure, plasma prolactin concentration, critical flicker fusion frequency and subjective 'alertness', 'contentedness' and 'anxiety' were measured at baseline and 2, 3, 4 and 5 h after drug ingestion. Data were analysed by analysis of variance with individual comparisons (Dunnett's test) with a significance criterion of P<0.05. Results Significant treatment effects (difference from placebo [mean, 95% CI] 5 h after drug ingestion) were as follows: clozapine reduced pupil diameter (mm; -3.02 [-3.56, -2.47]), salivary output (g; -0.34 [-0.60, -0.08]),mean arterial blood pressure (mm Hg; -8.7 [-14.3, -3.1]), critical flickerfusion frequency (Hz; -3.26 [-3.94, -2.58]), and subjectively-rated 'alertness' (mm; -20.94 [-29.21, -12.67]) and 'contentedness' (mm; -12.98 [-17.90, -8.06]), whereas haloperidol increased prolactin concentration (mU l(-1);301.3 [196.7, 405.8]) and caused small reductions in pupil diameter (mm; -0.68 [-1.23, -0.14]), mean arterial blood pressure (mm Hg; -7.0 [-12.6, -1.4]) and critical flicker fusion frequency (Hz; -1.15 [-1.83, -0.47]). Conclusions The effects of the antipsychotics are in agreement with their receptor binding profiles: <alpha>(1)-adrenoceptor blockade by clozapine may contribute to reductions in pupil diameter, salivation, mean arterial blood pressure and sedation, and muscarinic cholinoceptor blockade by the drugmay underlie the reduction in salivation. Conversely, D-2 dopamine receptor blockade by haloperidol is likely to be responsible for the increase in prolactin secretion evoked by the drug.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:21:58