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Titolo:
Target concentration intervention: beyond Y2K
Autore:
Holford, NHG;
Indirizzi:
Univ Auckland, Sch Med, Dept Pharmacol & Clin Pharmacol, Auckland, New Zealand Univ Auckland Auckland New Zealand lin Pharmacol, Auckland, New Zealand
Titolo Testata:
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
, volume: 52, anno: 2001, supplemento:, 1
pagine: 55S - 59S
SICI:
0306-5251(2001)52:<55S:TCIBY>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONCENTRATION-CONTROLLED TRIAL; AIRWAYS OBSTRUCTION; DRUGS;
Keywords:
target concentration intervention; therapeutic drug monitoring;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Holford, NHG Univ Auckland, Sch Med, Dept Pharmacol & Clin Pharmacol, Pk Rd,Private Bag92019, Auckland, New Zealand Univ Auckland Pk Rd,Private Bag 92019 Auckland New Zealand
Citazione:
N.H.G. Holford, "Target concentration intervention: beyond Y2K", BR J CL PH, 52, 2001, pp. 55S-59S

Abstract

Target concentration intervention (TCI) is proposed as an alternative conceptual strategy to therapeutic drug monitoring (TDM). It is argued that theidea of a therapeutic range has limited the interpretation of measured drug concentrations and diminished the anticipated clinical benefit to patients by use of an oversimplified pharmacodynamic model. TCI on the other hand embraces pharmacokinetic and pharmacodynamic concepts and uses the idea of a target effect and associated target concentration to make rational individual dose decisions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 08:57:33