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Titolo:
TP53 mutations, amplification of P63 and expression of cell cycle proteinsin squamous cell carcinoma of the oesophagus from a low incidence area in Western Europe
Autore:
Taniere, P; Martel-Planche, G; Saurin, JC; Lombard-Bohas, C; Berger, F; Scoazec, JY; Hainaut, P;
Indirizzi:
Int Agcy Res Canc, F-69372 Lyon 08, France Int Agcy Res Canc Lyon France08 Agcy Res Canc, F-69372 Lyon 08, France Hop Edouard Herriot, Federat Special Digest, F-69437 Lyon, France Hop Edouard Herriot Lyon France F-69437 ial Digest, F-69437 Lyon, France Hop Edouard Herriot, Serv Anat Pathol, F-69437 Lyon 03, France Hop EdouardHerriot Lyon France 03 Anat Pathol, F-69437 Lyon 03, France
Titolo Testata:
BRITISH JOURNAL OF CANCER
fascicolo: 5, volume: 85, anno: 2001,
pagine: 721 - 726
SICI:
0007-0920(20010901)85:5<721:TMAOPA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESOPHAGEAL CANCER; P27(KIP1) EXPRESSION; APOPTOSIS; ADENOCARCINOMA; OVEREXPRESSION; ASSOCIATION; INDUCTION; ABSENCE; TOBACCO; LINES;
Keywords:
oesophagus; squamous cell carcinoma; low-incidence area; TP53; P63; MDM2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Hainaut, P Int Agcy Res Canc, 150 Cours Albert Thomas, F-69372 Lyon 08, France Int Agcy Res Canc 150 Cours Albert Thomas Lyon France 08 rance
Citazione:
P. Taniere et al., "TP53 mutations, amplification of P63 and expression of cell cycle proteinsin squamous cell carcinoma of the oesophagus from a low incidence area in Western Europe", BR J CANC, 85(5), 2001, pp. 721-726

Abstract

In Europe, high incidence rates of oesophageal squamous cell carcinoma (SCCE) are observed in western France (Normandy and Brittany) and in north-eastern Italy. Analysis of TP53 mutations in tumours from these regions has shown a high prevalence of mutations at A:T basepairs that may result from DNA damage caused by specific mutagens. However, the spectrum of TP53 mutations in regions of low incidence is unknown. We report here TP53 mutation analysis in 33 SCCE collected in Lyon, an area of low incidence. These tumourswere also examined for MDM2 and P63 amplification, and for expression of p16(INK4a/CDKN2a), cyclin E, p27(Kipl) and Cox2. TP53 mutations were detected in 36% of the cases (12/33). In contrast with regions of high incidence, the mutation spectrum did not show a high prevalence of mutations at A:T base pairs. P63 was amplified in 5/32 cases tested (15.5%). No amplification of MDM2 was found. Expression studies revealed frequent loss of p16(INK4a/CDKN2a) (46%) and p27(Kipl) (25%) expression, and frequent overexpression ofCyclin E (70%) and Cox2 (42%). Overall, these results indicate that in Europe, SCCE from areas of high and low incidence present a similar pattern ofmolecular alterations but differ by the type of TP53 mutations. (C) 2001 Cancer Research Campaign.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:10:42