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Titolo:
Non-melanoma skin cancers and glucocorticoid therapy
Autore:
Karagas, MR; Cushing, GL; Greenberg, ER; Mott, LA; Spencer, SK; Nierenberg, DW;
Indirizzi:
Dartmouth Coll Sch Med, Dept Community & Family Med, Lebanon, NH 03756 USADartmouth Coll Sch Med Lebanon NH USA 03756 ly Med, Lebanon, NH 03756 USA Dartmouth Coll Sch Med, Dept Med, Lebanon, NH 03756 USA Dartmouth Coll SchMed Lebanon NH USA 03756 pt Med, Lebanon, NH 03756 USA Dartmouth Coll Sch Med, Dept Pharmacol & Toxicol, Lebanon, NH 03756 USA Dartmouth Coll Sch Med Lebanon NH USA 03756 oxicol, Lebanon, NH 03756 USA Dartmouth Coll Sch Med, Norris Cotton Canc Ctr, Lebanon, NH 03756 USA Dartmouth Coll Sch Med Lebanon NH USA 03756 nc Ctr, Lebanon, NH 03756 USA Mt Auburn Hosp, Cambridge, MA 02238 USA Mt Auburn Hosp Cambridge MA USA 02238 uburn Hosp, Cambridge, MA 02238 USA
Titolo Testata:
BRITISH JOURNAL OF CANCER
fascicolo: 5, volume: 85, anno: 2001,
pagine: 683 - 686
SICI:
0007-0920(20010901)85:5<683:NSCAGT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSPLANT RECIPIENTS; RENAL-TRANSPLANTATION; BASAL-CELL; TRENDS; NETHERLANDS; AUSTRALIA; CARCINOMA;
Keywords:
non-melanoma skin cancer; squamous cell carcinoma; basal cell carcinoma; glucocorticoids; immunosuppressive therapy; case-control study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Karagas, MR Dartmouth Coll Sch Med, Dept Community & Family Med, Lebanon, NH 03756 USA Dartmouth Coll Sch Med Lebanon NH USA 03756 non, NH 03756 USA
Citazione:
M.R. Karagas et al., "Non-melanoma skin cancers and glucocorticoid therapy", BR J CANC, 85(5), 2001, pp. 683-686

Abstract

Non-melanoma skin cancer (NMSC) is an important cause of morbidity and long-term mortality in organ transplant recipients receiving immunosuppressivedrugs such as azathioprine and cyclosporin, often combined with adrenocortical steroids (glucocorticoids). At lower doses, glucocorticoids alone are prescribed for other conditions including musculoskeletal, connective tissue and respiratory disorders. Presently, it is unknown whether patients taking glucocorticoids are at an increased risk of skin malignances. In a population-based case-control study in New Hampshire, USA, we compared use of glucocorticoids in 592 basal cell carcinoma (BCC) and 281 squamous cell carcinoma (SCC) cases and in 532 age and gender matched controls; neither cases nor controls had a history of organ transplantation. Participants underwenta structured personal interview regarding history of medication use and skin cancer risk factors. We used unconditional logistic regression analysis to compute odds ratios associated with glucocorticoid use for 1 month or longer while controlling for potential confounding factors. Risk of SCC was increased among users of oral glucocorticoids (adjusted odds ratio = 2.31; 95% CI = 1.27, 4.18), and risk of BCC was elevated modestly (adjusted odds ratio = 1.49; 95% CI = 0.90, 2.47). In contrast, risk of both SCC and BCC were unrelated to use of inhaled steroids. Our data suggest that use of oral glucocorticoids may increase risk of NMSC, and SCC in particular, among patients other than organ transplant recipients. We hypothesize that immunosuppression induced by oral glucocorticoids may allow these cancers to emerge from immunosurveillance. (C) 2001 Cancer Research Campaign.

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Documento generato il 02/12/20 alle ore 04:13:16