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Titolo:
Effects of central imidazolinergic and alpha(2)-adrenergic activation on water intake
Autore:
Sugawara, AM; Miguel, TT; Pereira, DTB; Menani, JV; De Luca, LA;
Indirizzi:
Univ Estadual Paulista, Fac Odontol, Dept Fisiol & Patol, BR-14801903 Araraquara, SP, Brazil Univ Estadual Paulista Araraquara SP Brazil BR-14801903BCara, SP, Brazil
Titolo Testata:
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
fascicolo: 9, volume: 34, anno: 2001,
pagine: 1185 - 1190
SICI:
0100-879X(200109)34:9<1185:EOCIAA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED 3-PERCENT NACL; CLONIDINE; RECEPTOR; SUBTYPES; SITES; BRAIN; RATS;
Keywords:
imidazolines; agmatine; UK 14304; guanabenz; alpha-methylnoradrenaline; thirst; dehydration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: De Luca, LA Univ Estadual Paulista, Fac Odontol, Dept Fisiol & Patol, Rua Humaita,1680, BR-14801903 Araraquara, SP, Brazil Univ Estadual Paulista RuaHumaita,1680 Araraquara SP Brazil BR-14801903 BC
Citazione:
A.M. Sugawara et al., "Effects of central imidazolinergic and alpha(2)-adrenergic activation on water intake", BRAZ J MED, 34(9), 2001, pp. 1185-1190

Abstract

Non-adrenergic ligands that bind to imidazoline receptors (I-R), a selective ligand that binds to alpha (2)-adrenoceptors (alpha (2)-AR) and mixed ligands that bind to both receptors were tested for their action on water intake behavior of 24-h water-deprived rats. All drugs were injected into the third cerebral ventricle. Except for agmatine (80 nmol), mixed ligands binding to 1-R/alpha (2)-AR such as guanabenz (40 nmol) and UK 14304 (20 nmol) inhibited water intake by 65% and up to 95% respectively. The selective non-imidazoline alpha (2)-AR agonist, alpha -methyl-noradrenaline, produced inhibition of water intake similar to that obtained with guanabenz, but at higher doses (80 nmol), The nonadrenergic 1-R ligands histamine (160 nmol, mixed histaminergic and imidazoline ligand) and imidazole-4-acetic acid (80 nmol, imidazoline ligand) did not alter water intake. The results show that selective, non-imidazoline alpha (2)-AR activation suppresses water intake.and suggest that the action on imidazoline sites by non-adrenergic ligandsis not sufficient to inhibit water intake.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:20:25