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Titolo:
A high-fructose diet induces insulin resistance but not blood pressure changes in normotensive rats
Autore:
Bezerra, RMN; Ueno, M; Silva, MS; Tavares, DQ; Carvalho, CRO; Saad, MJA; Gontijo, JAR;
Indirizzi:
Univ Estadual Campinas, Fac Ciencias Med, Dept Clin Med, Nucleo Med & Cirurgia Expt, BR-13081970 Campinas, SP, Brazil Univ Estadual Campinas Campinas SP Brazil BR-13081970 BCpinas, SP, Brazil Univ Estadual Campinas, Fac Econ & Adm, Dept Planejamento Alimentar & Nutr, BR-13081970 Campinas, SP, Brazil Univ Estadual Campinas Campinas SP Brazil BR-13081970 BCpinas, SP, Brazil
Titolo Testata:
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
fascicolo: 9, volume: 34, anno: 2001,
pagine: 1155 - 1160
SICI:
0100-879X(200109)34:9<1155:AHDIIR>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOSPHATIDYLINOSITOL 3-KINASE; INDUCED HYPERTENSION; PROTEIN-KINASE; EARLY STEPS; SENSITIVITY; TRANSPORT; AMELIORATION; LOSARTAN; SUCROSE; MUSCLE;
Keywords:
high-fructose diet; insulin resistance; blood pressure; hypertriglyceridemia; plasma cholesterol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Gontijo, JAR Univ Estadual Campinas, Fac Ciencias Med, Dept Clin Med, Nucleo Med & Cirurgia Expt, BR-13081970 Campinas, SP, Brazil Univ Estadual Campinas Campinas SP Brazil BR-13081970 BCazil
Citazione:
R.M.N. Bezerra et al., "A high-fructose diet induces insulin resistance but not blood pressure changes in normotensive rats", BRAZ J MED, 34(9), 2001, pp. 1155-1160

Abstract

Rats fed a high-fructose diet represent an animal model for insulin resistance and hypertension. We recently showed that a high-fructose diet containing vegetable oil but a normal sodium/potassium ratio induced mild insulin resistance with decreased insulin receptor substrate- 1 tyrosine phosphorylation in the liver and muscle of normal rats. In the present study, we examined the mean blood pressure, serum lipid levels and insulin sensitivity byestimating in vivo insulin activity using the 15-min intravenous insulin tolerance test (ITT, 0.5 ml of 6 mug insulin, iv) followed by calculation ofthe rate constant for plasma glucose disappearance (K-itt) in male Wistar-Hannover rats (110-130 g) randomly divided into four diet groups: control, 1:3 sodium/potassium ratio (R-Na:K) diet (C 1:3 R-Na:K); control, 1:1 sodium/potassium ratio diet (CNa 1:1 R-Na:K); high-fructose, 1:3 sodium/potassium ratio diet (F 1:3 R-Na:K). and high-fructose, 1:1 sodium/potassium ratio diet (FNa 1:1 R-Na:K) for 28 days. The change in R-Na:K for the control andhigh-fructose diets had no effect on insulin sensitivity measured by ITT. In contrast, the 1:1 R-Na:K increased blood pressure in rats receiving the control and high-fructose diets from 117 +/- 3 and 118 +/- 3 mmHg to 141 +/- 4 and 132 +/- 4 mmHg (P <0.05), respectively. Triacylglycerol levels werehigher in both groups treated with a high-fructose diet when compared to controls (C 1:3 R-Na:K: 1.2 +/- 0.1 mmol/l vs F 1:3 R-Na:K: 2.3 +/- 0.4 mmol/l and CNa 1: 1 R-Na:K: 1.2 +/- 0.2 mmol/l vs FNa 1:1 R-Na.K: 2.6 +/- 0.4 mmol/l, P <0.05). These data suggest that fructose alone does not induce hyperinsulinemia or hypertension in rats fed a normal R-Na:K diet, whereas an elevation of sodium in the diet may contribute to the elevated blood pressure in this animal model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 08:09:28