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Titolo:
Successful bone marrow transplantation for severe aplastic anemia following orthotopic liver transplantation: long-term follow-up and outcome
Autore:
Perkins, JL; Neglia, JP; Ramsay, NKC; Davies, SM;
Indirizzi:
Univ Minnesota, Div Pediat Hematol Oncol & Blood & Marrow Transpl, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 ranspl, Minneapolis, MN 55455 USA
Titolo Testata:
BONE MARROW TRANSPLANTATION
fascicolo: 5, volume: 28, anno: 2001,
pagine: 523 - 526
SICI:
0268-3369(200109)28:5<523:SBMTFS>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-C HEPATITIS; NON-B HEPATITIS; NON-A; MUCOEPIDERMOID CARCINOMA; MALIGNANCIES; RECIPIENTS; CHILDREN; FAILURE;
Keywords:
fulminant hepatic failure; non-A, non-B, non-C hepatitis; orthotopic liver transplantation; severe aplastic anemia; bone marrow transplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Perkins, JL Univ Minnesota, Div Pediat Hematol Oncol & Blood & Marrow Transpl, MMC 484,420 Delaware St SE, Minneapolis, MN 55455 USA Univ Minnesota MMC 484,420 Delaware St SE Minneapolis MN USA 55455
Citazione:
J.L. Perkins et al., "Successful bone marrow transplantation for severe aplastic anemia following orthotopic liver transplantation: long-term follow-up and outcome", BONE MAR TR, 28(5), 2001, pp. 523-526

Abstract

Severe aplastic anemia (SAA) is well described in children following livertransplantation for fulminant hepatic failure (FHF) secondary to non-A, non-B, non-C hepatitis, and is associated with a high mortality rate. Successful immunosuppressive treatment of SAA following liver transplantation has been reported, but death from infectious complications is not uncommon. We report the 8-year follow-up of a 3.5-year-old boy who underwent successful HLA-identical sibling donor bone marrow transplant for SAA 7 months following orthotopic liver transplant for non-A, non-B, non-C hepatitis. His post-bone marrow transplantation course was uneventful with no evidence of livertoxicity. Eight months following BMT he developed renal cell carcinoma metastatic to lymph nodes which was treated surgically. Six years following BMT he developed a mucoepidermoid carcinoma of the parotid gland also treatedsurgically. Despite these malignancies, he is currently well 8 years following liver and bone marrow transplantation, without signs of GVHD, growth failure or liver graft rejection. This is the first report of long-term follow-up of bone marrow transplantation for SAA following liver transplantation. The occurrence of two subsequent malignancies in this child underscores the need for close follow-up of future similar cases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:48:00