Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Allogeneic bone marrow transplantation-mediated transfer of specific immunity against Toxocara canis associated with excessive IgE
Autore:
Fischmeister, G; Holter, W; Matthes-Martin, S; Auer, H; Emminger-Schmidmeier, W; Gadner, H; Peters, C;
Indirizzi:
St Anna Childrens Hosp, Pediat Stem Cell Transplantat Unit, A-1090 Vienna,Austria St Anna Childrens Hosp Vienna Austria A-1090 Unit, A-1090 Vienna,Austria Univ Vienna, Dept Parasitol, Clin Inst Hyg, Vienna, Austria Univ Vienna Vienna Austria pt Parasitol, Clin Inst Hyg, Vienna, Austria
Titolo Testata:
BONE MARROW TRANSPLANTATION
fascicolo: 5, volume: 28, anno: 2001,
pagine: 519 - 521
SICI:
0268-3369(200109)28:5<519:ABMTTO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Keywords:
allogeneic BMT; Toxocara canis seroconversion; IgE elevation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Peters, C St Anna Childrens Hosp, Pediat Stem Cell Transplantat Unit, Kinderspital Gasse 6, A-1090 Vienna, Austria St Anna Childrens Hosp Kinderspital Gasse 6 Vienna Austria A-1090
Citazione:
G. Fischmeister et al., "Allogeneic bone marrow transplantation-mediated transfer of specific immunity against Toxocara canis associated with excessive IgE", BONE MAR TR, 28(5), 2001, pp. 519-521

Abstract

A girl with myelodysplastic syndrome (RAEB-T) received HLA-identical bone marrow from her younger brother after myeloablative treatment with busulfanand cyclophosphamide. After bone marrow transplantation, fever, exanthema,pruritis, and a pulmonary infiltrate were treated symptomatically. Bacterial cultures remained negative. Leukocyte engraftment began on day 10, and all blood cell populations proved to be of donor origin on FISH analysis. Increasing IgE levels (21 000 U/ml) on day 14 after BMT, positive RAST, specific IgG-antibodies, and missing Toxocara (T.) canis antigens in the recipient indicated donor-derived seroconversion. Before BMT, the recipient had been negative for T. canis in routine parasitological screening, and the donor proved to be positive for T. canis antibody by ELISA. This report suggests that the transfer of IgE immunity in the absence of detectable antigens may be responsible for IgE-mediated symptoms consistent with toxocara infection and confirms the need for parasite screening in donor medical examinations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 00:28:04