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Titolo:
Echogenicity of substantia nigra determined by transcranial ultrasound correlates with severity of parkinsonian symptoms induced by neuroleptic therapy
Autore:
Berg, D; Jabs, B; Merschdorf, U; Beckmann, H; Becker, G;
Indirizzi:
Univ Wurzburg, Dept Neurol, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 Neurol, D-97080 Wurzburg, Germany Univ Wurzburg, Dept Psychiat, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 ychiat, D-97080 Wurzburg, Germany
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 6, volume: 50, anno: 2001,
pagine: 463 - 467
SICI:
0006-3223(20010915)50:6<463:EOSNDB>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRUG-INDUCED PARKINSONISM; EXTRAPYRAMIDAL SYNDROMES; IRON; MOTOR; BRAIN;
Keywords:
neuroleptic induced parkinsonism (NIP); nigrostriatal system; subclinical injury; transcranial ultrasound; substantia nigra echogenicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Berg, D Univ Wurzburg, Dept Neurol, Josef Schneider Str 11, D-97080 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 11 Wurzburg Germany D-97080 any
Citazione:
D. Berg et al., "Echogenicity of substantia nigra determined by transcranial ultrasound correlates with severity of parkinsonian symptoms induced by neuroleptic therapy", BIOL PSYCHI, 50(6), 2001, pp. 463-467

Abstract

Background: Increased echogenicity of the substantia nigra (SN) detected by, transcranial sonography is, a characteristic ultrasound feature of Parkinson's disease. This ultrasound feature can also be detected in a subgroup of healthy, adults. In recent studies, healthy subjects with this ultrasound feature showed a reduced [F-18]-Dopa uptake on positron emission tomography (PET), indicating a subclinical alteration of the nigrostriatal system. This study was designed to evaluate whether the severity, of neuroleptic side effects is related to the echo-feature of the SN. Methods: In the retrospective part of the study, 93 psychiatric patients with either definite and severe parkinsonism after neuroleptic treatment (n = 52) or with no or minimal parkinsonian symptoms (n = 41) were included and underwent transcranial sonography to measure the extension of hyperechogenic areas at the SN. In addition, in the prospective part 11 patients with an acute psychotic episode requiring first-ever neuroleptic treatment underwent ultrasound examination. Subsequently, neuroleptic-induced parkinsoniansigns were assessed prospectively. Results: In the retrospective part of the study, patients with severe neuroleptic-induced parkinsonism had more extended echogenic signals at the SN than those with low echogenic SN (U-test; p < .01). The prospective part ofthe study showed that the severity of parkinsonian symptoms correlated with the echogenicity of the substantia nigra (Spearman's rank: p < .01). Conclusions: Increased echogenicity of the substantia nigra is associated with impaired function of the nigrostriatal system that can be disclosed byneuroleptic drugs. Biol Psychiatry 2001;50:463-467 (C) 2001 Society, of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 08:06:38