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Titolo:
Event-related potentials in schizophrenia during tonal and phonetic oddball tasks: Relations to diagnostic subtype, symptom features and verbal memory
Autore:
Bruder, GE; Kayser, J; Tenke, CE; Friedman, M; Malaspina, D; Gorman, JM;
Indirizzi:
New York State Psychiat Inst & Hosp, Dept Biopsychol, New York, NY 10032 USA New York State Psychiat Inst & Hosp New York NY USA 10032 k, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA New York State Psychiat Inst & Hosp, Dept Neurol, New York, NY 10032 USA New York State Psychiat Inst & Hosp New York NY USA 10032 k, NY 10032 USA New York State Psychiat Inst & Hosp, Lieber Ctr Schizophrenia Res, New York, NY 10032 USA New York State Psychiat Inst & Hosp New York NY USA 10032 k, NY 10032 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 6, volume: 50, anno: 2001,
pagine: 447 - 452
SICI:
0006-3223(20010915)50:6<447:EPISDT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
P300 ABNORMALITIES; TOPOGRAPHIES; MEDICATION; AMPLITUDE; REDUCTION; STATE; ERP;
Keywords:
event-related potentials; schizophrenia; paranoid subtype; symptoms; verbal memory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Bruder, GE New York State Psychiat Inst & Hosp, Dept Biopsychol, 1051 Riverside Dr,Unit 50, New York, NY 10032 USA New York State Psychiat Inst & Hosp 1051 Riverside Dr,Unit 50 New York NY USA 10032
Citazione:
G.E. Bruder et al., "Event-related potentials in schizophrenia during tonal and phonetic oddball tasks: Relations to diagnostic subtype, symptom features and verbal memory", BIOL PSYCHI, 50(6), 2001, pp. 447-452

Abstract

Background: This study, compares event-related potentials for paranoid patients (n = 13) versus matched undifferentiated patients and unmedicated patients (n = 14) versus matched healthy, adults. Methods: Event-related potentials of right-handed patients and control subjects were recorded from 30 electrodes during oddball tasks using consonant-vowel syllables or complex tones. Patients were also assessed using the Positive and Negative Syndrome Scale, the Thought Disorder Index, and the Wechsler Memory Scale. Results: Paranoid patients did not differ from undifferentiated patients in N1 or P3 amplitude but showed larger N2 at frontocentral sites to phonetic stimuli, as well as larger N2 over left than right hemisphere. Unmedicated patients showed reduced N2, but not N1 or P3, compared to control subjects. Conclusions: The N2 findings are consistent with neuropsychological evidence of greater verbal abilities and left hemisphere dominance in paranoid than nonparanoid schizophrenia. The findings also confirm the relationship ofP3 to total Brief Psychiatric Rating Scale score, negative symptoms, and verbal associative memory. Biol Psychiatry 2001;50:447-452 (C) 2001 Society,of Biological Psychiatry.

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Documento generato il 08/04/20 alle ore 08:59:30