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Titolo:
Vasopressin-deficient rats exhibit sensorimotor gating deficits that are reversed by subchronic haloperidol
Autore:
Feifel, D; Priebe, K;
Indirizzi:
Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA Univ Calif San Diego San Diego CA USA 92103 hiat, San Diego, CA 92103 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 6, volume: 50, anno: 2001,
pagine: 425 - 433
SICI:
0006-3223(20010915)50:6<425:VRESGD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFORMATION-PROCESSING DEFICITS; PREPULSE INHIBITION; BRATTLEBORO RATS; ACOUSTIC STARTLE; SCHIZOPHRENIC-PATIENTS; ANIMAL-MODEL; DOPAMINE; BRAIN; CLOZAPINE; GENE;
Keywords:
prepulse inhibition; schizophrenia; vasopressin; haloperidol; antipsychotic; Brattleboro rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Feifel, D Univ Calif San Diego, Dept Psychiat, 200 W Arbor Dr, San Diego, CA 92103 USA Univ Calif San Diego 200 W Arbor Dr San Diego CA USA 92103 3 USA
Citazione:
D. Feifel e K. Priebe, "Vasopressin-deficient rats exhibit sensorimotor gating deficits that are reversed by subchronic haloperidol", BIOL PSYCHI, 50(6), 2001, pp. 425-433

Abstract

Background: Brattleboro (BB) rats are Long Evans rats with a single base pair genetic mutation that impairs their ability, to synthesize vasopressin,a neurotransmitter and neurohormone. Brattleboro rats are known to have deficits in memory, emotional reactivity, motivation, attention, and social recognition, abnormalities associated with schizophrenia. Prepulse inhibition (PPI) of the acoustic startle reflex (ASR) is a measure of sensorimotor gating. Prepulse inhibition is deficient in unmedicated schizophrenia patients, and PPI deficits in schizophrenia may be related to the cognitive and behavioral abnormalities associated with this disorder. In this study we tested the hypothesis that BB rats exhibit PPI deficits analogous to those exhibited by schizophrenia patients. Methods: In one experiment, BB rats homozygous (BB-Ho) or heterozygous (BB-Hz) for the mutated vasopressin gene were compared with normal Long Evans (LE) rats from the same breeder source. In separate studies, BB-Ho and LE rats were treated with acute or subchronic (22 days) injections of haloperidol. Results: Both BB-Ho and BB-Hz rats had significantly, higher ASR and significantly lower PPI compared with LE rats, with BB-Ho rats exhibiting the lowest PPI among all three genotypes. Furthermore, a single subcutaneous (SC)injection of haloperidol (0.5 mg/kg) did not reverse the PPI deficits in BB rats. In contrast, daily SC administration of haloperidol for 22 days reversed PPI deficits in BB rats. Conclusions: These results suggest that PPI deficient BB rats may, be an important genetic model of PPI deficits, which may help elucidate genetic, pharmacologic, and pathophysiologic mechanisms underlying PPI deficits and the effects of antipsychotic drugs on PPI. Biol Psychiatry 2001;50:425-433 (C) 2001 Society, of Biological Psychiatry.

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Documento generato il 23/01/20 alle ore 18:27:48