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Titolo:
Sensorimotor gating deficits in bipolar disorder patients with acute psychotic mania
Autore:
Perry, W; Minassian, A; Feifel, D; Braff, DL;
Indirizzi:
Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA Univ Calif SanDiego La Jolla CA USA 92093 ychiat, La Jolla, CA 92093 USA Calif Sch Profess Psychol, San Diego, CA 92121 USA Calif Sch Profess Psychol San Diego CA USA 92121 San Diego, CA 92121 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 6, volume: 50, anno: 2001,
pagine: 418 - 424
SICI:
0006-3223(20010915)50:6<418:SGDIBD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOTYPAL PERSONALITY-DISORDER; INFORMATION-PROCESSING DEFICITS; PREPULSE INHIBITION DEFICITS; HUMAN STARTLE REFLEX; SCHIZOPHRENIC-PATIENTS; ACOUSTIC STARTLE; THOUGHT-DISORDER; HABITUATION; MEDICATION; SCALE;
Keywords:
bipolar disorder; habituation; psychosis; prepulse inhibition; sensorimotor gating; startle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Perry, W Univ Calif San Diego, Dept Psychiat, 200 W Arbor Dr Mail Code 8218, La Jolla, CA 92093 USA Univ Calif San Diego 200 W Arbor Dr Mail Code 8218 La Jolla CA USA 92093
Citazione:
W. Perry et al., "Sensorimotor gating deficits in bipolar disorder patients with acute psychotic mania", BIOL PSYCHI, 50(6), 2001, pp. 418-424

Abstract

Background: Deficits in sensorimotor gating as assessed by prepulse inhibition (PPI) and habituation of the human startle response have been noted inschizophrenia and other patients with known dysfunction in the brain substrates that regulate PPI. During acute mania, bipolar disorder (BD) and schizophrenia patients present with symptoms that are similar. To determine if these clinical similarities extend to neurophysiologic domains, PPI and startle habituation were assessed in BD patients with acute psychotic mania and compared with a sample of acutely psychotic schizophrenia patients and a normal comparison group. Methods: Fifteen BD patients, 16 schizophrenia patients, and 17 control subjects were assessed on PPI and startle habituation. Results: The BD patients had significantly lower PPI than did the control subjects in two of the three PPI conditions (60- and 120-msec interstimulusintervals) as well as less startle habituation. The BD patients did not statistically differ from the schizophrenia patients in PPI or habituation. Conclusions: These findings of sensorimotor gating deficits among bipolar disorder patients are consistent with other findings using different measures of information processing and suggest that the neurobiological substrates underlying sensorimotor gating may be dysregulated during acute manic andpsychotic states. Biol Psychiatry 2001;50:418-424 (C) 2001 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 13:58:05