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Titolo:
Proteinase inhibitors from the medicinal leech Hirudo medicinalis
Autore:
Baskova, IP; Zavalova, LL;
Indirizzi:
Moscow MV Lomonosov State Univ, Sch Biol, Moscow 119899, Russia Moscow MV Lomonosov State Univ Moscow Russia 119899 oscow 119899, Russia Russian Acad Sci, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia Russian Acad Sci Moscow Russia 117997 oorgan Chem, Moscow 117997, Russia
Titolo Testata:
BIOCHEMISTRY-MOSCOW
fascicolo: 7, volume: 66, anno: 2001,
pagine: 703 - 714
SICI:
0006-2979(200107)66:7<703:PIFTML>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAST-CELL TRYPTASE; AMINO-ACID-SEQUENCE; PANCREATIC TRYPSIN-INHIBITOR; THROMBIN-SPECIFIC INHIBITOR; SERINE-PROTEASE INHIBITOR; HUMAN-LEUKOCYTE ELASTASE; RAY CRYSTAL-STRUCTURE; HUMAN ALPHA-THROMBIN; KAZAL-TYPE INHIBITOR; EGLIN-C;
Keywords:
medicinal leech; bdellins; eglins; hirustasin; tryptase inhibitor; factor Xa inhibitor; hirudin; carboxypeptidase inhibitor; component complement inhibitor; trypsin; chymotrypsin; thrombin; kallikrein; subtilisin; granulocyte elastase; granulocyte cathepsin G;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
118
Recensione:
Indirizzi per estratti:
Indirizzo: Baskova, IP Moscow MV Lomonosov State Univ, Sch Biol, Moscow 119899, Russia Moscow MV Lomonosov State Univ Moscow Russia 119899 , Russia
Citazione:
I.P. Baskova e L.L. Zavalova, "Proteinase inhibitors from the medicinal leech Hirudo medicinalis", BIOCHEM-MOS, 66(7), 2001, pp. 703-714

Abstract

The medicinal leech Hirudo medicinalis produces various types of proteinase inhibitors: bdellins (inhibitors of trypsin, plasmin, and acrosin), hirustasin (inhibitor of tissue kallikrein, trypsin, alpha -chymotrypsin, and granulocyte cathepsin G), tryptase inhibitor, eglins (inhibitors of alpha -chymotrypsin, subtilisin, and chymasin and the granulocyte proteinases elastase and cathepsin G), inhibitor of factor Xa, hirudin (thrombin inhibitor), inhibitor of carboxypeptidase, and inhibitor of complement component C1s. This review summarizes data on their primary and tertiary structures, actionmechanisms, and biological activities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 15:23:49