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Titolo:
Effects of vagal and splanchnic section on food intake, weight, serum leptin and hypothalamic neuropeptide Y in rat
Autore:
Furness, JB; Koopmans, HS; Robbins, HL; Clerc, N; Tobin, JM; Morris, MJ;
Indirizzi:
Univ Melbourne, Dept Anat & Cell Biol, Melbourne, Vic 3010, Australia UnivMelbourne Melbourne Vic Australia 3010 elbourne, Vic 3010, Australia Univ Calgary, Dept Physiol, Calgary, AB, Canada Univ Calgary Calgary AB Canada algary, Dept Physiol, Calgary, AB, Canada CNRS, Neurobiol Lab, F-13402 Marseille 20, France CNRS Marseille France 20 RS, Neurobiol Lab, F-13402 Marseille 20, France Univ Melbourne, Dept Pharmacol, Melbourne, Vic 3010, Australia Univ Melbourne Melbourne Vic Australia 3010 elbourne, Vic 3010, Australia
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 1-2, volume: 92, anno: 2001,
pagine: 28 - 36
SICI:
1566-0702(20010917)92:1-2<28:EOVASS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; BODY-WEIGHT; OBESE GENE; FEEDING-BEHAVIOR; INDUCED SATIETY; SMALL-INTESTINE; SUBSTANCE-P; VAGOTOMY; LESIONS; NUCLEUS;
Keywords:
satiety; vagotomy; splanchnic nerves; leptin; neuropeptide Y;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Furness, JB Univ Melbourne, Dept Anat & Cell Biol, Melbourne, Vic 3010, Australia Univ Melbourne Melbourne Vic Australia 3010 c 3010, Australia
Citazione:
J.B. Furness et al., "Effects of vagal and splanchnic section on food intake, weight, serum leptin and hypothalamic neuropeptide Y in rat", AUTON NEURO, 92(1-2), 2001, pp. 28-36

Abstract

Truncal vagotomy can cause reduced food intake and weight loss in humans and laboratory animals. In order to investigate some of the factors that might contribute to this effect, we studied changes in ingestive behaviour, whole body and organ weights, serum leptin and hypothalamic neuropeptide Y inrats with bilateral vagal section, bilateral splanchnic nerve section and combined vagotomy plus splanchnectomy. Pyloromyotomy was combined,with vagotomy to lessen effects of vagotomy on gastric emptying. Animals with vagotomy or vagotomy plus splanchnectomy lost weight and decreased their daily food intake relative to animals with splanchnectomy alone, rats with bilateral sham exposure of one or both nerve; or rats with pyloromyotomy alone. Serum leptin and white fat mass, 4 weeks after vagotomy, were about 20% of thevalues in the sham-operated animals at this time. No effect for splanchnicnerve section alone was observed. Pyloromyotomy caused no reduction in weight or fat mass, but reduced serum leptin. Following vagotomy with or without splanchnic nerve section, neuropeptide Y was elevated in the arcuate nucleus relative to values for the other four groups. Changes in neuropeptide Y were inversely correlated with levels of serum leptin. It is concluded that the effect of vagotomy could be due to the loss of a feeding signal carried by vagal afferent neurons, or to changed humoral signals, for example, increased production of a satiety hormone. However, it cannot be attributed to signals that reduce feeding (for example, gastric distension) reaching the central nervous system via the splanchnic nerves. The changes were sufficient to cause weight loss even though serum leptin wasdecreased, a change that would be expected to increase food intake. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 22/01/20 alle ore 09:31:27