Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Results of an open, non-placebo controlled pilot study investigating the immunomodulatory potential of autovaccine
Autore:
Rusch, V; Ottendorfer, D; Zimmermann, K; Gebauer, F; Schrodl, W; Nowak, P; Skarabis, H; Kunze, R;
Indirizzi:
Inst Mikrookol, D-35745 Herborn, Germany Inst Mikrookol Herborn Germany D-35745 krookol, D-35745 Herborn, Germany Affina Immuntech GmbH, Berlin, Germany Affina Immuntech GmbH Berlin Germany na Immuntech GmbH, Berlin, Germany Praxis Allgemeinmed Peter Nowak, Berlin, Germany Praxis Allgemeinmed PeterNowak Berlin Germany r Nowak, Berlin, Germany Free Univ Berlin, Inst Stat & Empir Methoden, Berlin, Germany Free Univ Berlin Berlin Germany Stat & Empir Methoden, Berlin, Germany
Titolo Testata:
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
fascicolo: 8, volume: 51, anno: 2001,
pagine: 690 - 697
SICI:
0004-4172(2001)51:8<690:ROAONC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY BOWEL-DISEASE; BIOLOGICAL-ACTIVITIES; MUCOSAL INFLAMMATION; LIPID-A; LIPOPOLYSACCHARIDE; RESPONSES; GAMMA; FLORA;
Keywords:
autovaccine; acute-phase proteins; cellular immunity; cytokines; humoral immunity; rough E. coli;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Zimmermann, K Inst Mikrookol, Auf den Luppen 8, D-35745 Herborn, Germany Inst Mikrookol Auf den Luppen 8 Herborn Germany D-35745 any
Citazione:
V. Rusch et al., "Results of an open, non-placebo controlled pilot study investigating the immunomodulatory potential of autovaccine", ARZNEI-FOR, 51(8), 2001, pp. 690-697

Abstract

Autovaccines are prepared from autologous, human, non-pathogenic, "rough" variants of E. coli derived from the stool flora of individuals according to a highly standardized procedure. As a fundamental concept within microbiological therapy, these autovaccines are mainly used to treat chronic inflammatory disorders associated with Impaired Immune reactions resistant to standard therapeutic treatments. Generally, Immunomodulatory effects of outer membrane components or cell wall fragments of gram-negative bacteria on Innate or adaptive immunity are widely accepted but nevertheless mechanisms ofactions of these autovaccines remained obscure, despite some recent publications about other autovaccine preparations of different origin. Hence, immunomodulating properties of autovaccine were investigated In a pilot study with 78 outpatients with variable disorders ranging from recurrent respiratory infections to diffuse gastrointestinal complaints. Patients received their autologous bacteria parenterally In increasing doses. Before application and 4 to 6 weeks after application of autovaccine, blood samples of the patients were taken to investigate a range of immunological parameters such as acute phase proteins, serum antibodies and cytokines. The results revealed that autovaccines were able to modulate significantly the release of three potent immunoregulatory cytokines e.g. interferon-gamma, granulocyte-macrophage-colony stimulating factor and interleukin-1 beta, whereas specific humoral immunity remained largely unaffected. From these results It may be concluded that the autovaccine mainly act antigen non-specifically on the cytokine level rather than Inducing a specific vaccination. Further studies with more detailed kinetic measurements of cytokines will have to verify these results.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:50:42