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Titolo:
Differential metabolism of human VLDL according to content of ApoE and ApoC-III
Autore:
Tomiyasu, K; Walsh, BW; Ikewaki, K; Judge, H; Sacks, FM;
Indirizzi:
Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA Harvard UnivBoston MA USA 02115 bl Hlth, Dept Nutr, Boston, MA 02115 USA Brigham & Womens Hosp, Dept Obstet & Gynecol, Boston, MA 02115 USA Brigham& Womens Hosp Boston MA USA 02115 & Gynecol, Boston, MA 02115 USA Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Channing Lab, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 t Med,Channing Lab, Boston, MA 02115 USA
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 9, volume: 21, anno: 2001,
pagine: 1494 - 1500
SICI:
1079-5642(200109)21:9<1494:DMOHVA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY LIPOPROTEINS; TRIGLYCERIDE-RICH LIPOPROTEINS; HUMAN APOLIPOPROTEIN-E; HEPARAN-SULFATE; RECEPTOR; BINDING; EXPRESSION; PLASMA; CIII; RAT;
Keywords:
lipoproteins; metabolism; apolipoprotein B; apolipoprotein E; apolipoprotein C-III;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Sacks, FM Harvard Univ, Sch Publ Hlth, Dept Nutr, 665 Huntington Ave, Boston, MA 02115 USA Harvard Univ 665 Huntington Ave Boston MA USA 02115 MA 02115 USA
Citazione:
K. Tomiyasu et al., "Differential metabolism of human VLDL according to content of ApoE and ApoC-III", ART THROM V, 21(9), 2001, pp. 1494-1500

Abstract

We studied the metabolism of very low density lipoprotein (VLDL) and intermediate density lipoprotein (IDL) particles that did or did not have apolipoprotein E (apoE) in 12 normolipidemic women by endogenously labeling plasma apolipoprotein B. The plasma was separated into bound (E+) and unbound (E-) fractions by use of a monoclonal antibody (1D7), and the fractions were ultracentrifuged to yield E+ and E- subfractions of light and dense VLDL and IDL. VLDL E+ and IDL E+ were produced mainly by the liver. VLDL E+ and IDL E+ had lower fractional catabolic rates and much higher apolipoprotein C-III (apoC-III) content than did the corresponding E-particles. Most light VLDL apoE+ underwent lipolysis to dense VLDL E+ with reduced apoC-III content, which was removed from the circulation without conversion to IDL. In contrast, most light VLDL apoE-, poor in apoC-III, was removed from the circulation, and a smaller proportion underwent lipolysis to dense VLDL E-. Most dense VLDL E-underwent lipolysis to IDL E-. The rate constant for lipolysisof dense VLDL to IDL was greater for E- than for E+, and the rate constantfor clearance from plasma was greater for dense VLDL E+ than for E-. In conclusion, metabolism of human VLDL particles is influenced by their contentof apoE, further modulated by the coexistence of apoC-III.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:13:20