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Titolo:
Protection from obesity in mice lacking the VLDL receptor
Autore:
Goudriaan, JR; Tacken, PJ; Dahlmans, VEH; Gijbels, MJJ; van Dijk, KW; Havekes, LM; Jong, MC;
Indirizzi:
TNO, Gaubius Lab, NL-2301 CE Leiden, Netherlands TNO Leiden Netherlands NL-2301 CE us Lab, NL-2301 CE Leiden, Netherlands Leiden Univ, Med Ctr, MGC Dept Human Genet, Leiden, Netherlands Leiden Univ Leiden Netherlands GC Dept Human Genet, Leiden, Netherlands Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands Leiden Univ Leiden Netherlands d Ctr, Dept Cardiol, Leiden, Netherlands Leiden Univ, Med Ctr, Dept Internal Med, Leiden, Netherlands Leiden Univ Leiden Netherlands , Dept Internal Med, Leiden, Netherlands
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 9, volume: 21, anno: 2001,
pagine: 1488 - 1493
SICI:
1079-5642(200109)21:9<1488:PFOIML>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY-LIPOPROTEIN RECEPTOR; TRIGLYCERIDE-RICH LIPOPROTEINS; HUMAN APOLIPOPROTEIN C1; FREE FATTY-ACIDS; TRANSGENIC MICE; CHYLOMICRON REMNANTS; KNOCKOUT MICE; GENE-TRANSFER; PROTEIN; EXPRESSION;
Keywords:
VLDL receptor; obesity; fatty acid transport; triglyceride metabolism; transgenic mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Havekes, LM TNO, Gaubius Lab, Zernikedreef 9,POB 2215, NL-2301 CE Leiden, Netherlands TNO Zernikedreef 9,POB 2215 Leiden Netherlands NL-2301 CE nds
Citazione:
J.R. Goudriaan et al., "Protection from obesity in mice lacking the VLDL receptor", ART THROM V, 21(9), 2001, pp. 1488-1493

Abstract

It has previously been reported that mice lacking the VLDL receptor (VLDLR-/-) exhibit normal plasma lipid levels and a modest decrease in adipose tissue mass. In the present study, the effect of VLDLR deficiency on profoundweight gain was studied in mice. Obesity was induced either by feeding of a high-fat, high-calorie (HFC) diet or by crossbreeding mice onto the genetically obese ob/ob background. After 17 weeks of HFC feeding, VLDLR-/- miceremained lean, whereas their wild-type littermates (VLDLR+/+) became obese. Similarly, the weight gain of ob/ob mice was less profound in the absenceof the VLDLR. Moreover, VLDLR deficiency led to increased plasma triglycerides after HFC feeding. The protection from obesity in VLDLR-/- mice involved decreased peripheral uptake of fatty acids, because VLDLR-/- mice exhibited a significant reduction in whole-body free fatty acid uptake, with no clear differences in food intake and fat absorption. These observations weresupported by a strong decrease in average adipocyte size in VLDLR-/- mice of both obesity models, implying reduced adipocyte triglyceride storage in the absence of the VLDLR. These results suggest that the VLDLR plays a rolein the delivery of VLDL-derived fatty acids into adipose tissue.

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Documento generato il 23/09/20 alle ore 05:18:29