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Titolo:
Angiotensin II administration to atherosclerotic mice increases macrophageuptake of oxidized LDL - A possible role for interleukin-6
Autore:
Keidar, S; Heinrich, R; Kaplan, M; Hayek, T; Aviram, M;
Indirizzi:
Rambam Med Ctr, IL-31096 Haifa, Israel Rambam Med Ctr Haifa Israel IL-31096 bam Med Ctr, IL-31096 Haifa, Israel Technion Israel Inst Technol, Fac Med, Rappaport Family Inst Res Med Sci, Lipid Res Lab, Haifa, Israel Technion Israel Inst Technol Haifa Israel Lipid Res Lab, Haifa, Israel
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 9, volume: 21, anno: 2001,
pagine: 1464 - 1469
SICI:
1079-5642(200109)21:9<1464:AIATAM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
E-DEFICIENT MICE; LOW-DENSITY-LIPOPROTEIN; RECEPTOR ANTAGONIST; ENDOTHELIAL-CELLS; LIPID-PEROXIDATION; EXPRESSION; OXIDATION; METABOLISM; CAPTOPRIL; LOSARTAN;
Keywords:
angiotensin; losartan; oxidized LDL; CD36; interleukin-6; macrophages; atherosclerosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Keidar, S Rambam Med Ctr, IL-31096 Haifa, Israel Rambam Med Ctr Haifa Israel IL-31096 r, IL-31096 Haifa, Israel
Citazione:
S. Keidar et al., "Angiotensin II administration to atherosclerotic mice increases macrophageuptake of oxidized LDL - A possible role for interleukin-6", ART THROM V, 21(9), 2001, pp. 1464-1469

Abstract

The goal of the present study was to elucidate mechanisms for angiotensin II (Ang II) induction of oxidized low density lipoprotein (Ox-LDL) uptake by macrophages, the hallmark of early atherosclerosis. Compared with placebotreatment, Ang II injections (0.1 mL, 10(-7) mol/L per day) for 2 weeks toapolipoprotein E-deficient mice significantly increased Ox-LDL degradation, CD36 mRNA expression, and CD36 protein expression by their peritoneal macrophages (MPMs). These effects were abolished by treatment with losartan (5to 50 mg/kg per day) before Ang II administration. Because no such effect was obtained in vitro, the ex vivo effect of Ang IT on macrophage uptake ofOx-LDL could be mediated by a factor that is not expressed at a significant level in vitro. Because Ang II stimulates cellular production of interleukin-6 (IL-6), we analyzed the possible role of IL-6 as a mediator of Ang II-mediated cellular uptake of Ox-LDL by using several approaches. First, incubations of IL-6 with MPM or IL-6 administration in mice increased macrophage Ox-LDL degradation and CD36 mRNA expression. Second, injection of IL-6 receptor antibodies in mice during Ang II treatment reduced macrophage Ox-LDL uptake and CD36 expression compared treatment with Ang II alone. Finally,Ang II treatment of IL-6-deficient mice did not affect their MPM Ox-LDL uptake and CD36 protein levels. Thus, we conclude that a novel mechanism for Ang II atherogenicity, related to macrophage cholesterol accumulation and foam cell formation, may involve its stimulatory effect on macrophage uptakeof Ox-LDL, a process mediated by IL-6.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:39:21