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Titolo:
Human blood-derived macrophages induce apoptosis in human plaque-derived vascular smooth muscle cells by Fass-ligand/Fas interactions
Autore:
Boyle, JJ; Bowyer, DE; Weissberg, PL; Bennett, MR;
Indirizzi:
Addenbrookes Hosp, Unit Cardiovasc Med, Cambridge, England Addenbrookes Hosp Cambridge England Cardiovasc Med, Cambridge, England Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England Univ Cambridge Cambridge England CB2 1QP hol, Cambridge CB2 1QP, England
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 9, volume: 21, anno: 2001,
pagine: 1402 - 1407
SICI:
1079-5642(200109)21:9<1402:HBMIAI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATHEROSCLEROTIC PLAQUES; P53-MEDIATED APOPTOSIS; INTERFERON-GAMMA; HUMAN-MONOCYTES; DEATH; EXPRESSION; PROLIFERATION; INSTABILITY; MECHANISMS; LESIONS;
Keywords:
macrophages; atherosclerosis; apoptosis; smooth muscle cells, vascular; Fas;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Boyle, JJ Hammersmith Hosp, Imperial Coll Sch Med, Dept Histopathol, Du Cane Rd, London W12 0NN, England Hammersmith Hosp Du Cane Rd London England W12 0NN 0NN, England
Citazione:
J.J. Boyle et al., "Human blood-derived macrophages induce apoptosis in human plaque-derived vascular smooth muscle cells by Fass-ligand/Fas interactions", ART THROM V, 21(9), 2001, pp. 1402-1407

Abstract

Human atherosclerotic plaques that rupture are characterized by relativelylow vascular smooth muscle cell (VSMC) and high inflammatory cell contents. Ruptured plaques also contain higher numbers of apoptotic VSMCs than do stable lesions, suggesting that VSMC apoptosis may promote plaque rupture. We examined the ability of human monocytes/macrophages to induce apoptosis of VSMCs derived from human carotid plaque, aortic media, and coronary media. Macrophages, but not T lymphocytes, induced a dose-dependent apoptosis ofVSMCs, which required monocyte maturation to macrophages and direct cell-cell contact/proximity. VSMC apoptosis was inhibited by neutralizing antibodies to Fas-ligand (Fas-L) or an Fas-Fc fusion protein, indicating the requirement for membrane-bound Fas and Fas-L. Monocyte maturation was associatedwith increased surface expression of Fas-L, coincident with the onset of cytotoxicity. VSMCs expressed surface Fas, which was increased in plaque VSMCs, and plaque VSMCs also underwent Fas-induced apoptosis. We conclude thathuman macrophages potently induce human VSMC apoptosis, which requires direct cell-cell interactions and is in part dependent on Fas/Fas-L interactions. Macrophage-induced VSMC apoptosis may therefore directly promote plaquerupture.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:40:56