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Titolo:
Pharmacokinetic profiles of nevirapine and indinavir in various fractions of seminal plasma
Autore:
van Praag, RME; Repping, S; de Vries, JWA; Lange, JMA; Hoetelmans, RMW; Prins, JM;
Indirizzi:
Univ Amsterdam, Acad Med Ctr, Dept Internal Med,Natl Aids Therapy Evaluat Ctr, Div Infect Dis Trop Med & AIDS, NL-1105 AZ Amsterdam, Netherlands UnivAmsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Obstet & Gynaecol, Ctr Reprod Med, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Slotervaart Hosp, Dept Pharm & Pharmacol, Amsterdam, Netherlands Slotervaart Hosp Amsterdam Netherlands harmacol, Amsterdam, Netherlands
Titolo Testata:
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
fascicolo: 10, volume: 45, anno: 2001,
pagine: 2902 - 2907
SICI:
0066-4804(200110)45:10<2902:PPONAI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; IMMUNODEFICIENCY-VIRUS TYPE-1; HIV-1-INFECTED INDIVIDUALS; ULTRAVIOLET DETECTION; PROTEASE INHIBITORS; TRIPLE THERAPY; SEMEN; RITONAVIR; PENETRATION; SUPPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Prins, JM Univ Amsterdam, Acad Med Ctr, Dept Internal Med,Natl Aids Therapy Evaluat Ctr, Div Infect Dis Trop Med & AIDS, Meibergdreef 9,room F4-217, NL-1105 AZAmsterdam, Netherlands Univ Amsterdam Meibergdreef 9,room F4-217 Amsterdam Netherlands NL-1105 AZ
Citazione:
R.M.E. van Praag et al., "Pharmacokinetic profiles of nevirapine and indinavir in various fractions of seminal plasma", ANTIM AG CH, 45(10), 2001, pp. 2902-2907

Abstract

Limited data are available on antiretroviral drug concentrations in seminal plasma during a dosing interval. Further, since human ejaculate is composed of fluids originating from the testes, the seminal vesicles, and the prostate, all having different physiological characteristics, drug concentrations in total seminal plasma do not necessarily reflect concentrations in the separate compartments. Five human immunodeficiency virus type 1-infected patients on nevirapine (NVP; 200 mg twice a day [b.i.d.]) and/or indinavir (IDV; 800 mg b.i.d. with ritonavir, 100 mg b.i.d.) regimens used a split ejaculate technique to separate seminal plasma in two fractions, representingfluids from the testes and prostate (first fraction) and fluids from the seminal vesicles (second fraction). Split-ejaculate samples were provided at0, 2, 5, and 8 h after drug ingestion, on separate days after 3 days of sexual abstinence. NVP and IDV showed time-dependent concentrations in seminal plasma, with peak concentrations in both fractions at 2 and 2 to 5 h, respectively, after drug ingestion. The NVP concentrations were not significantly different between the first and second fractions of the ejaculate at all time points measured and were in the therapeutic range, except for the predose concentration in two patients. The median (range) predose IDV concentrations in the first and second fractions of the ejaculate were 448 (353 to1,015) ng/ml and 527 (240 to 849) ng/ml, respectively (P = 0.7). In conclusion, NVP and IDV concentrations in seminal plasma are dependent on the time after drug ingestion. Furthermore, our data suggest that NVP and IDV achieve therapeutic concentrations in both the testes and prostate and the seminal vesicles throughout the dosing interval.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 04:04:54