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Titolo:
Some aspects of immunology of the bovine uterus related to treatments for endometritis
Autore:
Dhaliwal, GS; Murray, RD; Woldehiwet, Z;
Indirizzi:
Univ Liverpool, Dept Vet Clin Sci & Anim Husb, Vet Field Stn, Wirral CH64 7TE, Merseyside, England Univ Liverpool Wirral Merseyside England CH64 7TETE, Merseyside, England Univ Liverpool, Dept Vet Pathol, Vet Field Stn, Wirral CH64 7TE, Merseyside, England Univ Liverpool Wirral Merseyside England CH64 7TE TE, Merseyside, England
Titolo Testata:
ANIMAL REPRODUCTION SCIENCE
fascicolo: 3-4, volume: 67, anno: 2001,
pagine: 135 - 152
SICI:
0378-4320(20010915)67:3-4<135:SAOIOT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESCHERICHIA-COLI ENDOTOXIN; RETAINED FETAL MEMBRANES; SUPPRESSED ENDOGENOUS PRODUCTION; UTERINE DEFENSE-MECHANISMS; INTERROGANS SEROVAR HARDJO; F-SERIES PROSTAGLANDINS; EARLY POSTPARTUM PERIOD; SERPIN-LIKE PROTEINS; DAIRY-COWS; ESTROUS-CYCLE;
Keywords:
cattle-uterus; endometritis; uterine defense; immunomodulators;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
143
Recensione:
Indirizzi per estratti:
Indirizzo: Murray, RD Univ Liverpool, Dept Vet Clin Sci & Anim Husb, Vet Field Stn, Wirral CH64 7TE, Merseyside, England Univ Liverpool Wirral Merseyside England CH64 7TE ide, England
Citazione:
G.S. Dhaliwal et al., "Some aspects of immunology of the bovine uterus related to treatments for endometritis", ANIM REPROD, 67(3-4), 2001, pp. 135-152

Abstract

Endometritis in breeding cattle occurs during the postpartum period. and is associated primarily with contamination of the reproductive tract involving Arcanobacter pyogenes (formerly Actinomyces pyogenes) together with Gram-negative anaerobes. Polymorphonuclear inflammatory cells (PMNs) contributepartly to the defense mechanisms against micro-organisms contaminating thevagina and uterine lumen, whose phagocytic activity depends on bacterial opsonisation by humoral antibodies, significant numbers of lymphocytes are also present. Whilst leukocyte numbers in the uterine lumen are relatively high during metoestrus and dioestrus compared to other phases of the oestrous cycle, their functional activity is unaffected. Humoral antibody concentrations in the reproductive tract are stimulated following exposure to localantigen, and the response is site dependent; of the several different classes of immunoglobulins, IgG predominates in the uterus and IgA the vagina. Only a portion of the total IgG(1) found on the uterine lumen is synthesised locally in the endometrium, the remainder and all of the IgG(2) is derived from the local uterine blood supply. Generally, concentrations of immunosuppressant proteins present in the uterine lumen increase under progesterone dominance, and these inhibit lymphocyte proliferation, making the uterus more susceptible to infection. The relationship between uterine susceptibility to micro-organism contamination and the luteal phase of the oestrous cycle is still unclear. Intrauterine infusion of immunomodulators such as E. coli lipopolysaccharides (LPS) or oyster glycogen, in healthy cows and those with endometritis, stimulates leukocytes to migrate into the uterine lumen. At a dosage rate of 100 mug, lipopolysaccharides are not absorbed by thehealthy endometrium and do not alter the oestrous cycle length. It is unknown, whether a similar dose can be absorbed through an inflamed endometriumin naturally occurring cases of endometritis to cause systemic illness. Currently, prostaglandin F-2 alpha is recommended for treating endometritis in both cycling and noncycling cows, but its mode of action in non-cycling cows is not fully understood. The efficacy of endometritis treatment using an intrauterine infusion of an immunomodulator in cases occurring naturally has not been determined on a large scale. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:29:51