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Titolo:
Endothelial function and myogenic reactivity in small mesenteric arteries of hyperlipidemic pregnant rats
Autore:
Ramirez, RJJ; Novak, J; Johnston, TP; Gandley, RE; McLaughlin, MK; Hubel, CA;
Indirizzi:
Univ Pittsburgh, Sch Med, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA15213 USA Univ Pittsburgh Pittsburgh PA USA 15213 prod Sci, Pittsburgh, PA15213 USA Magee Womens Res Inst, Dept OB GYN, Pittsburgh, PA 15213 USA Magee Womens Res Inst Pittsburgh PA USA 15213 N, Pittsburgh, PA 15213 USA Univ Missouri, Sch Pharm, Div Pharmaceut Sci, Kansas City, MO 64110 USA Univ Missouri Kansas City MO USA 64110 eut Sci, Kansas City, MO 64110 USA Coll St Catherine, St Paul, MN 55105 USA Coll St Catherine St Paul MN USA55105 t Catherine, St Paul, MN 55105 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 4, volume: 281, anno: 2001,
pagine: R1330 - R1337
SICI:
0363-6119(200110)281:4<R1330:EFAMRI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPOPROTEIN-LIPASE GENE; FREE FATTY-ACIDS; SERUM TRIGLYCERIDES; PREECLAMPSIA; PLASMA; HYPERTRIGLYCERIDEMIA; PHENOTYPE; MALONDIALDEHYDE; VASODILATION; ASSOCIATION;
Keywords:
pregnancy; poloxamer 407; triglyceride; malondialdehyde; resistance vasculature;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Hubel, CA Magee Womens Res Inst, Dept OB GYN, 204 Craft Ave, Pittsburgh, PA 15213 USA Magee Womens Res Inst 204 Craft Ave Pittsburgh PA USA 15213 USA
Citazione:
R.J.J. Ramirez et al., "Endothelial function and myogenic reactivity in small mesenteric arteries of hyperlipidemic pregnant rats", AM J P-REG, 281(4), 2001, pp. R1330-R1337

Abstract

Supraphysiological increases in serum triglycerides and cholesterol often occur during pregnancy, but their effects on vascular function are poorly understood. Intraperitoneal injection of the nontoxic surfactant poloxamer 407 (P-407) results in sustained elevation of triglycerides and cholesterol. We asked if P-407-induced hyperlipidemia during late pregnancy adversely affects mesenteric resistance artery vasodilator function. On days 13-15 of pregnancy, rats were given a single intraperitoneal injection of P-407, sterile water vehicle, or non-lipid-altering pluronic F-88 (P-88). Four days postinjection, serum triglycerides, cholesterol, free fatty acids, and the lipid peroxidation product malondialdehyde were significantly increased in P-407-treated rats. Mesenteric arteries from P-407-treated rats displayed significant increases in myogenic reactivity (constrictor responses to step increases in intraluminal pressure). The nitric oxide (NO) blocker N-alpha-methyl-L-arginine increased the myogenic response in control but not in P-407 arteries, normalizing group differences. Endothelial removal increased myogenic reactivity beyond that of prior NO synthase inhibition in controls and potentiated myogenic reactivity in P-407 arteries such that responses again converged. Relaxation responses to the endothelium-dependent vasodilator methacholine did not differ. We conclude that that P-407-induced hyperlipidemia during pregnancy increases myogenic reactivity due to selective attenuation of an NO-mediated vasodilator component of the myogenic response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:48:33