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Titolo:
Cardiovascular changes induced by central hypertonic saline are accompanied by glutamate release in awake rats
Autore:
Jin, QH; Ueda, Y; Ishizuka, Y; Kunitake, T; Kannan, H;
Indirizzi:
Miyazaki Med Coll, Dept Physiol, Miyazaki 8891692, Japan Miyazaki Med Coll Miyazaki Japan 8891692 hysiol, Miyazaki 8891692, Japan Miyazaki Med Coll, Dept Psychiat, Miyazaki 8891692, Japan Miyazaki Med Coll Miyazaki Japan 8891692 ychiat, Miyazaki 8891692, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 4, volume: 281, anno: 2001,
pagine: R1224 - R1231
SICI:
0363-6119(200110)281:4<R1224:CCIBCH>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-FOS EXPRESSION; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; OSMOTIC STIMULATION; AMINO-ACIDS; SUPRAOPTIC NUCLEUS; ANGIOTENSIN-II; HYPEROSMOTIC STIMULATION; INVIVO MICRODIALYSIS; NEUROSECRETORY-CELLS; DIPSOGENIC RESPONSES;
Keywords:
paraventricular nucleus; blood pressure; heart rate; microdialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Kannan, H Miyazaki Med Coll, Dept Physiol, 5200 Kihara, Miyazaki 8891692, Japan Miyazaki Med Coll 5200 Kihara Miyazaki Japan 8891692 692, Japan
Citazione:
Q.H. Jin et al., "Cardiovascular changes induced by central hypertonic saline are accompanied by glutamate release in awake rats", AM J P-REG, 281(4), 2001, pp. R1224-R1231

Abstract

To elucidate neurochemical mechanisms responsible for cardiovascular responses induced by central salt loading, we directly perfused the paraventricular nucleus (PVN) of the hypothalamus region with hypertonic saline (0.3 or0.45 M) by using an in vivo brain microdialysis technique. We then measured the extracellular concentrations of glutamate in the PVN region in conscious rats along with the blood pressure and heart rate. Blood pressure, heart rate, and glutamate levels were increased by perfusion of 0.45 M saline; however, they did not change by perfusion of 0.3 M saline. Next, we examined the possible involvement of glutamate in the cardiovascular responses induced by hypertonic saline. Dizocilpine, a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, attenuated the increases of blood pressure and heart rate, although 6-cyano-7-nitroquinoxaline-2,3-dione, an antagonist of the non-NMDA receptor, did not affect the blood pressure and heart rate. Our results show that local perfusion of the hypothalamic PVN region with hypertonic saline elicits a local release of glutamate, which may act via NMDA-type glutamate receptors to produce cardiovascular responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 12:48:53