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Titolo:
Activation of the kallikrein-kinin system by cardiopulmonary bypass in humans
Autore:
Campbell, DJ; Dixon, B; Kladis, A; Kemme, M; Santamaria, JD;
Indirizzi:
St Vincents Inst Med Res, Fitzroy, Vic 3065, Australia St Vincents Inst Med Res Fitzroy Vic Australia 3065 , Vic 3065, Australia St Vincents Hosp, Dept Intens Care, Fitzroy, Vic 3065, Australia St Vincents Hosp Fitzroy Vic Australia 3065 Fitzroy, Vic 3065, Australia Tech Univ Darmstadt, Inst Biochem, D-64287 Darmstadt, Germany Tech Univ Darmstadt Darmstadt Germany D-64287 D-64287 Darmstadt, Germany
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 4, volume: 281, anno: 2001,
pagine: R1059 - R1070
SICI:
0363-6119(200110)281:4<R1059:AOTKSB>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING-ENZYME-INHIBITOR; HUMAN TISSUE KALLIKREIN; PROTEIN-C INHIBITOR; HUMAN-PLASMA; INFLAMMATORY RESPONSE; BINDING-PROTEIN; BRADYKININ ANTAGONIST; CARDIAC-SURGERY; CONTACT SYSTEM; PREKALLIKREIN;
Keywords:
contact system; bradykinin; kallidin; angiotensin-converting enzyme inhibition; kininogen; kallistatin; aprotinin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Campbell, DJ St Vincents Inst Med Res, 41 Victoria Parade, Fitzroy, Vic 3065, Australia St Vincents Inst Med Res 41 Victoria Parade Fitzroy Vic Australia 3065
Citazione:
D.J. Campbell et al., "Activation of the kallikrein-kinin system by cardiopulmonary bypass in humans", AM J P-REG, 281(4), 2001, pp. R1059-R1070

Abstract

We used cardiopulmonary bypass (CPB) as a model of activation of the contact system and investigated the involvement of the plasma and tissue kallikrein-kinin systems (KKS) in this process. Circulating levels of bradykinin and kallidin and their metabolites, plasma and tissue kallikrein, low and high molecular weight kininogen, and kallistatin were measured before, during, and 1, 4, and 10 h after CPB in subjects undergoing cardiac surgery. Bradykinin peptide levels increased 10- to 20-fold during the first 10 min, returned toward basal levels by 70 min of CPB, and remained 1.2- to 2.5-fold elevated after CPB. Kallidin peptide levels showed little change during CPB,but they were elevated 1.7- to 5.2-fold after CPB. There were reductions of 80 and 60% in plasma and tissue kallikrein levels, respectively, during the first minute of CPB. Kininogen and kallistatin levels were unchanged. Angiotensin-converting enzyme inhibition did not amplify the increase in bradykinin levels during CPB. Aprotinin administration prevented activation of the KKS. The changes in circulating kinin and kallikrein levels indicate activation of both the plasma and tissue KKS during activation of the contactsystem by CPB.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 09:56:53