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Titolo:
Redox regulation of endothelial barrier integrity
Autore:
Zhao, XY; Alexander, JS; Zhang, S; Zhu, YN; Sieber, NJ; Aw, TY; Carden, DL;
Indirizzi:
Louisiana State Univ, Sch Med, Hlth Sci Ctr, Dept Mol & Cell Physiol, Shreveport, LA 71130 USA Louisiana State Univ Shreveport LA USA 71130 ol, Shreveport, LA 71130 USA Louisiana State Univ, Hlth Sci Ctr, Dept Med, Shreveport, LA 71130 USA Louisiana State Univ Shreveport LA USA 71130 ed, Shreveport, LA 71130 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
fascicolo: 4, volume: 281, anno: 2001,
pagine: L879 - L886
SICI:
1040-0605(200110)281:4<L879:RROEBI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; INTESTINAL ISCHEMIA-REPERFUSION; HYDROGEN-PEROXIDE; XANTHINE-OXIDASE; EXPIRED BREATH; CELL-JUNCTIONS; VE-CADHERIN; GLUTATHIONE; INJURY; PERMEABILITY;
Keywords:
cadherin; microvascular permeability; oxidants; redox imbalance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Carden, DL Louisiana State Univ, Sch Med, Hlth Sci Ctr, Dept Mol & Cell Physiol, 1501Kings Highway,POB 33932, Shreveport, LA 71130 USA Louisiana State Univ 1501 Kings Highway,POB 33932 Shreveport LA USA 71130
Citazione:
X.Y. Zhao et al., "Redox regulation of endothelial barrier integrity", AM J P-LUNG, 281(4), 2001, pp. L879-L886

Abstract

Intestinal ischemia-reperfusion is associated with the generation of reactive oxygen metabolites as well as remote, oxidant-mediated lung injury. Oxidants elicit endothelial redox imbalance and loss of vascular integrity by disorganizing several junctional proteins that contribute to the maintenance and regulation of the endothelial barrier. To determine the specific effect of redox imbalance on pulmonary vascular barrier integrity, microvascular permeability was determined in lungs of animals subjected to chemically induced redox imbalance. The effect of redox imbalance on microvascular permeability and endothelial junctional integrity in cultured lung microvascular cells was also determined. Whole lung and cultured pulmonary endothelial cell permeability both increased significantly in response to chemical redox imbalance. Thiol depletion also resulted in decreased endothelial cadherin content and disruption of the endothelial barrier. These deleterious effects of intracellular redox imbalance were blocked by pretreatment with exogenous glutathione. The results of this study suggest that redox imbalance contributes to pulmonary microvascular dysfunction by altering the content and/or spatial distribution of endothelial junctional proteins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:34:26