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Titolo:
Effect of glutamine supplementation on exercise-induced changes in lymphocyte function
Autore:
Krzywkowski, K; Petersen, EW; Ostrowski, K; Kristensen, JH; Boza, J; Pedersen, BK;
Indirizzi:
Rigshosp, Dept Infect Dis M7721, DK-2200 Copenhagen N, Denmark Rigshosp Copenhagen Denmark N t Dis M7721, DK-2200 Copenhagen N, Denmark Rigshosp, Copenhagen Muscle Res Ctr, DK-2200 Copenhagen, Denmark RigshospCopenhagen Denmark DK-2200 Res Ctr, DK-2200 Copenhagen, Denmark Rigshosp, Dept Orthoped Med & Rehabil, DK-2200 Copenhagen N, Denmark Rigshosp Copenhagen Denmark N d & Rehabil, DK-2200 Copenhagen N, Denmark Nestle Res Ctr, CH-100 Lausanne, Switzerland Nestle Res Ctr Lausanne Switzerland CH-100 CH-100 Lausanne, Switzerland
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
fascicolo: 4, volume: 281, anno: 2001,
pagine: C1259 - C1265
SICI:
0363-6143(200110)281:4<C1259:EOGSOE>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID-CONCENTRATIONS; KILLER-CELL ACTIVITY; IMMUNE-SYSTEM; PLASMA; BLOOD; STRESS; PROLIFERATION; NUTRITION; INFECTION; MUSCLE;
Keywords:
training; physical activity; immunology; natural killer cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Pedersen, BK Rigshosp, Dept Infect Dis M7721, Tagensvej 20, DK-2200 Copenhagen N, Denmark Rigshosp Tagensvej 20 Copenhagen Denmark N nhagen N, Denmark
Citazione:
K. Krzywkowski et al., "Effect of glutamine supplementation on exercise-induced changes in lymphocyte function", AM J P-CELL, 281(4), 2001, pp. C1259-C1265

Abstract

The purpose of this study was to investigate the possible role of glutamine in exercise-induced impairment of lymphocyte function. Ten male athletes participated in a randomized, placebo-controlled, double-blind crossover study. Each athlete performed bicycle exercise for 2 h at 75% of maximum O-2 consumption on 2 separate days. Glutamine or placebo supplements were givenorally during and up to 2 h postexercise. The trial induced postexercise neutrocytosis that lasted at least 2 h. The total lymphocyte count increasedby the end of exercise due to increase of both CD3(+)TCR alpha beta (+) and CD3(+)TCR gamma delta (+) T cells as well as CD3(-)CD16(+)CD56(+) naturalkiller (NK) cells. Concentrations of CD8(+) and CD4(+) T cells lacking CD28 and CD95 on their surface increased more than those of cells expressing these receptors. Within the CD4(+) cells, only CD45RA(-) memory cells, but not CD45RA(+) naive cells, increased in response to exercise. Most lymphocyte subpopulations decreased 2 h after exercise. Glutamine supplementation abolished the postexercise decline in plasma glutamine concentration but had no effect on lymphocyte trafficking, NK and lymphokine-activated killer cell activities, T cell proliferation, catecholamines, growth hormone, insulin, or glucose. Neutrocytosis was less pronounced in the glutamine-supplemented group, but it is unlikely that this finding is of any clinical significance. This study does not support the idea that glutamine plays a mechanistic role in exercise-induced immune changes.

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Documento generato il 07/04/20 alle ore 22:24:42